Abstract: Clostridioides difficile is recognized as the predominant pathogen for antimicrobial associated diarrhea and health care facility-associated infectious diarrhea, and is also listed as one of the urgent threat associated with antibiotics by Centers for Disease Control and Prevention of USA. In recent decades, studies on C. difficile and the rate of C. difficile infection increased dramatically. The aim of this study was to analyze the epidemiological characteristics of C. difficile infection and summarize research progress of C. difficile in China, which might help the further studies of C. difficile in China.