顾琳, 宋衍燕, 张士尧, 郝民, 李丽, 李倩, 孙灵利. 新型冠状病毒疑似感染病例下呼吸道病原谱分析[J]. 疾病监测, 2021, 36(12): 1291-1294. DOI: 10.3784/jbjc.202012230431
引用本文: 顾琳, 宋衍燕, 张士尧, 郝民, 李丽, 李倩, 孙灵利. 新型冠状病毒疑似感染病例下呼吸道病原谱分析[J]. 疾病监测, 2021, 36(12): 1291-1294. DOI: 10.3784/jbjc.202012230431
Gu Lin, Song Yanyan, Zhang Shiyao, Hao Min, Li Li, Li Qian, Sun Lingli. Pathogen spectrum in lower respiratory tracts of suspected case infected with SARS-CoV-2[J]. Disease Surveillance, 2021, 36(12): 1291-1294. DOI: 10.3784/jbjc.202012230431
Citation: Gu Lin, Song Yanyan, Zhang Shiyao, Hao Min, Li Li, Li Qian, Sun Lingli. Pathogen spectrum in lower respiratory tracts of suspected case infected with SARS-CoV-2[J]. Disease Surveillance, 2021, 36(12): 1291-1294. DOI: 10.3784/jbjc.202012230431

新型冠状病毒疑似感染病例下呼吸道病原谱分析

Pathogen spectrum in lower respiratory tracts of suspected case infected with SARS-CoV-2

  • 摘要:
      目的  了解2020年1 — 3月北京市朝阳区100例新型冠状病毒(SARS-CoV-2)疑似感染病例的下呼吸道病原谱。
      方法  采用实时荧光定量聚合酶链式反应(real-time PCR)方法检测疑似病例痰标本中28种呼吸道病原,包括 14种病毒、11种细菌、肺炎支原体、肺炎衣原体、真菌。
      结果  100份SARS-CoV-2疑似感染病例痰标本中,所检测病原核酸阳性率为72.00%(72/100),SARS-CoV-2阳性率为15.00%(15/100),革兰阴性菌、革兰阳性菌、真菌、肺炎支原体、肺炎衣原体的阳性率分别为32.00%(32/100)、24.00%(24/100)、39.00%(39/100)、6.00%(6/100)、3.00%(3/100),甲型流感病毒、乙型流感病毒、腺病毒、呼吸道合胞病毒、鼻病毒均有检出。 混合感染(同时检出≥2种病原)的检出率为35.00%(35/100)。 15份SARS-CoV-2阳性标本中混合感染标本13份。
      结论  北京市朝阳区2020年1 — 3月的100例SARS-CoV-2疑似感染病例的下呼吸道病原谱多样,以真菌、SARS-CoV-2、金黄色葡萄球菌、流感嗜血杆菌为主,SARS-CoV-2阳性病例下呼吸道混合感染以金黄色葡萄球菌合并真菌为主。

     

    Abstract:
      Objective  To understand the pathogen spectrum in the lower respiratory tracts of 100 suspected cases infected with SARS-CoV-2 in Chaoyang district of Beijing from January to March, 2020.
      Methods  A total of 28 kinds of respiratory pathogens were detected by real-time fluorescent quantitative polymerase chain reaction (PCR), including 14 viruses and 11 bacteria, as well as Mycoplasma pneumoniae, Chlamydia pneumoniae and fungi.
      Results  The positive rate of nucleic acid of detected pathogens in 100 sputum samples of the suspected cases was 72.00% (72/100). The positive rate of SARS-CoV-2 was 15.00% (15/100). The positive rates of gram-negative bacteria, gram-positive bacteria, fungi, Mycoplasma pneumoniae and Chlamydia pneumoniae were 32.00% (32/100), 24.00% (24/100), 39.00% (39/100), 6.00% (6/100) and 3.00% (3/100), respectively. Influenza A virus, influenza B virus, adenovirus, respiratory syncytial virus and rhinovirus were also detected. A total of 13 samples were positive with both SARS-CoV-2 and other pathogens.
      Conclusion  The pathogens detected in the lower respiratory tracts of 100 suspected cases infected with SARS-CoV-2 in Chaoyang from January to March in 2020 was diverse. Fungi, SARS-CoV-2, Staphylococcus aureus and Haemophilus influenzae were the main pathogens. S. aureus and fungi were the main co-infected pathogens detected in the lower respiratory tracts of suspected SARS-CoV-2 infection cases.

     

/

返回文章
返回