新埃立克体病研究进展

李紫薇 尹家祥

李紫薇, 尹家祥. 新埃立克体病研究进展[J]. 疾病监测, 2022, 37(12): 1604-1609. doi: 10.3784/jbjc.20206270302
引用本文: 李紫薇, 尹家祥. 新埃立克体病研究进展[J]. 疾病监测, 2022, 37(12): 1604-1609. doi: 10.3784/jbjc.20206270302
Li Ziwei, Yin Jiaxiang. Research progress in study of neoehrlichiosis[J]. Dis Surveill, 2022, 37(12): 1604-1609. doi: 10.3784/jbjc.20206270302
Citation: Li Ziwei, Yin Jiaxiang. Research progress in study of neoehrlichiosis[J]. Dis Surveill, 2022, 37(12): 1604-1609. doi: 10.3784/jbjc.20206270302

新埃立克体病研究进展

doi: 10.3784/jbjc.20206270302
基金项目: 国家自然科学基金(No. 81860565);“兴滇英才支持计划”项目经费支持(No. YNWR-MY-2019-008);云南省高校自然疫源性疾病流行病学科技创新团队[云教发(2020)102号]
详细信息
    作者简介:

    李紫薇,女,安徽省界首市人,研究生在读,主要从事自然疫源性疾病流行病学研究,Email:lzw1041540577@163.com

    通讯作者:

    尹家祥,Tel:0872−2123785,Email:chinayjx@hotmail.com

  • 中图分类号: R211; R183.5

Research progress in study of neoehrlichiosis

Funds: This study was supported by the National Natural Science Foundation of China (No. 81860565), the project of “Talent Support Program in Yunnan” (No. YNWR-MY-2019-008), the Science and Technology Innovation Team of Natural Focal Diseases Epidemiology in University of Yunnan Province (Yunnan Provincial Department of Education issued [2020] No. 102)
More Information
  • 摘要: 新埃立克体病是一种新发的蜱传自然疫源性疾病。 2010年瑞典首次报道该病,目前欧洲和亚洲多个国家均有流行。 本研究对新埃立克体病的病原学、流行病学、临床表现及诊断治疗的相关研究进展进行综述,旨在提高临床和疾控人员对新埃立克体病的认知,增强诊治和防控能力,并为今后深入研究奠定基础。
  • 表  1  新埃立克体病患者基本情况

    Table  1.   Basic information of patients with Neoehrlichiosis

    国家确诊时间
    (年)
    年龄
    (岁)
    性别基础病史接受过的药物治疗脾切
    除术
    参考
    文献
    德国 2007 69 慢性炎症性脱髓鞘性多发性神经病 环磷酰胺、皮质类固醇、利妥昔单抗 3
    2008 57
    捷克 2008 55 套细胞淋巴瘤 利妥昔单抗、阿糖胞苷、米托蒽醌、甲氨蝶呤 4
    2009 58 原发性硬化性胆管炎、B细胞淋巴瘤 利妥昔单抗
    瑞士 2009 61 主动脉瓣关闭不全、三尖瓣关闭不全 5
    2011 68 慢性淋巴细胞白血病 6
    2012 58 淋巴瘤 利妥昔单抗、 环磷酰胺、 多柔比星、 长春新碱、 强的松
    瑞典 2009 77 慢性B细胞淋巴细胞白血病 皮质类固醇、环磷酰胺 7
    2011 75 慢性淋巴细胞白血病 硫唑嘌呤、皮质类固醇 8
    2011 67 滤泡性淋巴瘤、系统性红斑狼疮 皮质类固醇
    2013 67 颗粒淋巴细胞白血病、银屑病关节炎 环磷酰胺、皮质类固醇
    2013 54 银屑病 环磷酰胺、皮质类固醇
    2013 59 弥漫大 B 细胞淋巴瘤、类风湿关节炎 环磷酰胺
    2014 78 类风湿关节炎 甲氨蝶呤、利妥昔单抗 9
    2014 55 肉芽肿性多血管炎 利妥昔单抗
    2014 57 急性B淋巴细胞型白血病 硫唑嘌呤、甲氨蝶呤、皮质类固醇
    2015 71 类风湿关节炎 甲氨蝶呤 10
    2017 57 多发性硬化症 利妥昔单抗 11
    2019 48 多发性硬化症 利妥昔单抗 12
    瑞典  2019 54 肉芽肿性多血管炎 利妥昔单抗、白介素-1受体拮抗剂、皮质类固醇 12
    2019 62 多发性硬化症 利妥昔单抗
    不详 58 滤泡性淋巴瘤 利妥昔单抗 13
    不详 63 低丙种球蛋白血症
    不详 65 自身免疫性溶血性贫血 免疫抑制剂
    中国 2010 35 14, 17
    2010 67
    2010 50
    2010 29
    2010 37
    2010 58
    2010 41
    斯洛文尼亚 2019 66 弥漫大B细胞淋巴瘤 利妥昔单抗、 环磷酰胺、 多柔比星、 长春新碱、 强的松 15
    法国 2021 54 16
    2021 67 慢性淋巴细胞白血病 依鲁替尼
    2021 61
      2021 66 滤泡性淋巴瘤
    下载: 导出CSV

    表  2  不同国家和人群的新埃立克体病感染情况

    Table  2.   Neoehrlichiosis infection in different countries and populations

    报告年份国家调查人群检测方法核酸阳性率(%)核酸阳性病例数/疑似病例数参考文献
    2012 中国 蜱叮咬发热患者 巢式PCR 1.13 7/622 17
    2014 波兰 林业工作者 巢式 PCR 1.58 5/316 18
    2015 瑞典 蜱叮咬患者 荧光定量PCR 1.96 2/102 19
    2016 荷兰 蜱叮咬及游走性红斑患者 荧光定量PCR 1.12 7/626 20
    2017 挪威 蜱叮咬患者 荧光定量PCR 10.00 7/70 21
    2018 瑞典 疑似无形体病患者 荧光定量PCR 1.98 2/101 13
    2021 法国 疑似无形体病患者 荧光定量 PCR 0.43 4/934 16
    2021 奥地利 蜱叮咬患者 荧光定量 PCR 2.21 11/498 22
    注:PCR. 聚合酶链式反应
    下载: 导出CSV
  • [1] Grankvist A, Jaén-Luchoro D, Wass L, et al. Comparative Genomics of Clinical Isolates of the Emerging Tick-Borne Pathogen Neoehrlichia mikurensis[J]. Microorganisms, 2021, 9(7): 1488. DOI:  10.3390/microorganisms9071488.
    [2] Silaghi C, Beck R, Oteo JA, et al. Neoehrlichiosis: an emerging tick-borne zoonosis caused by Candidatus Neoehrlichia mikurensis[J]. Exp Appl Acarol, 2016, 68(3): 279–297. DOI: 10.1007/s10493−015−9935−y.
    [3] von Loewenich FD, Geissdörfer W, Disqué C, et al. Detection of “Candidatus Neoehrlichia mikurensis” in two patients with severe febrile illnesses: evidence for a European sequence variant[J]. J Clin Microbiol, 2010, 48(7): 2630–2635. DOI: 10.1128/JCM.00588−10.
    [4] Pekova S, Vydra J, Kabickova H, et al. Candidatus Neoehrlichia mikurensis infection identified in 2 hematooncologic patients: benefit of molecular techniques for rare pathogen detection[J]. Diagn Microbiol Infect Dis, 2011, 69(3): 266–270. DOI:  10.1016/j.diagmicrobio.2010.10.004.
    [5] Fehr JS, Bloemberg GV, Ritter C, et al. Septicemia caused by tick-borne bacterial pathogen Candidatus Neoehrlichia mikurensis[J]. Emerg Infect Dis, 2010, 16(7): 1127–1129. DOI:  10.3201/eid1607.091907.
    [6] Maurer FP, Keller PM, Beuret C, et al. Close geographic association of human neoehrlichiosis and tick populations carrying “Candidatus Neoehrlichia mikurensis” in eastern Switzerland[J]. J Clin Microbiol, 2013, 51(1): 169–176. DOI: 10.1128/JCM.01955−12.
    [7] Welinder-Olsson C, Kjellin E, Vaht K, et al. First case of human “Candidatus Neoehrlichia mikurensis” infection in a febrile patient with chronic lymphocytic leukemia[J]. J Clin Microbiol, 2010, 48(5): 1956–1959. DOI: 10.1128/JCM.02423−09.
    [8] Grankvist A, Andersson PO, Mattsson M, et al. Infections with the tick-borne bacterium “Candidatus Neoehrlichia mikurensis” mimic noninfectious conditions in patients with B cell malignancies or autoimmune diseases[J]. Clin Infect Dis, 2014, 58(12): 1716–1722. DOI:  10.1093/cid/ciu189.
    [9] Grankvist A, Moore ER, Svensson Stadler L, et al. Multilocus Sequence Analysis of Clinical Candidatus Neoehrlichia mikurensis Strains from Europe[J]. J Clin Microbiol, 2015, 53(10): 3126–3132. DOI: 10.1128/JCM.00880−15.
    [10] Andréasson K, Jönsson G, Lindell P, et al. Recurrent fever caused by Candidatus Neoehrlichia mikurensis in a rheumatoid arthritis patient treated with rituximab.[J]. Rheumatology (Oxford, England) , 2015, 54(2): 369–371. DOI:  10.1093/rheumatology/keu441.
    [11] Dadgar A, Grankvist A, Wernbro L, et al. Fever of unknown origin in a multiple sclerosis patient on immunomodulatory therapy was due to neoehrlichiosis[J]. Lakartidningen, 2017, 114: EM6L.
    [12] Wass L, Grankvist A, Bell-Sakyi L, et al. Cultivation of the causative agent of human neoehrlichiosis from clinical isolates identifies vascular endothelium as a target of infection[J]. Emerg Microbes Infect, 2019, 8(1): 413–425. DOI:  10.1080/22221751.2019.1584017.
    [13] Wass L, Grankvist A, Mattsson M, et al. Serological reactivity to Anaplasma phagocytophilum in neoehrlichiosis patients[J]. Eur J Clin Microbiol Infect Dis, 2018, 37(9): 1673–1678. DOI: 10.1007/s10096−018−3298−3.
    [14] 黎浩. 两种虫媒传染病自然疫源地调查与病原特征研究[D]. 北京: 中国人民解放军军事医学科学院, 2013.

    Li H. Investigations on natural foci and pathogenic characteristics of two vector-borne diseases[D]. Beijing: Acad Mil Med Sci, 2013.
    [15] Lenart M, Simoniti M, Strasek-Smrdel K, et al. Case report: first symptomatic Candidatus Neoehrlichia mikurensis infection in Slovenia[J]. BMC Infect Dis, 2021, 21(1): 579. DOI: 10.1186/s12879−021−06297−z.
    [16] Boyer PH, Baldinger L, Degeilh B, et al. The emerging tick-borne pathogen Neoehrlichia mikurensis: first French case series and vector epidemiology[J]. Emerg Microbes Infect, 2021, 10(1): 1731–1738. DOI:  10.1080/22221751.2021.1973347.
    [17] Li H, Jiang JF, Liu W, et al. Human infection with Candidatus Neoehrlichia mikurensis, China[J]. Emerg Infect Dis, 2012, 18(10): 1636–1639. DOI:  10.3201/eid1810.120594.
    [18] Welc-Falęciak R, Sisńki E, Kowalec M, et al. Asymptomatic “Candidatus Neoehrlichia mikurensis” infections in immunocompetent humans[J]. J Clin Microbiol, 2014, 52(8): 3072–3074.DOI. DOI: 10.1128/JCM.00741−14.
    [19] Grankvist A, Sandelin LL, Andersson J, et al. Infections with Candidatus Neoehrlichia mikurensis and Cytokine Responses in 2 Persons Bitten by Ticks, Sweden[J]. Emerg Infect Dis, 2015, 21(8): 1462–1465. DOI:  10.3201/eid2108.150060.
    [20] Jahfari S, Hofhuis A, Fonville M, et al. Molecular detection of tick-borne pathogens in humans with tick bites and erythema migrans, in the Netherlands[J]. PLoS Negl Trop Dis, 2016, 10(10): e5042. DOI:  10.1371/journal.pntd.0005042.
    [21] Quarsten H, Grankvist A, Hoyvoll L, et al. Candidatus Neoehrlichia mikurensis and Borrelia burgdorferi sensu lato detected in the blood of Norwegian patients with erythema migrans[J]. Ticks Tick Borne Dis, 2017, 8(5): 715–720. DOI:  10.1016/j.ttbdis.2017.05.004.
    [22] Markowicz M, Schötta AM, Höss D, et al. Infections with Tickborne Pathogens after Tick Bite, Austria, 2015−2018[J]. Emerg Infect Dis, 2021, 27(4): 1048–1056. DOI:  10.3201/eid2704.203366.
    [23] Wennerås C. Infections with the tick-borne bacterium Candidatus Neoehrlichia mikurensis[J]. Clin Microbiol Infect, 2015, 21(7): 621–630. DOI:  10.1016/j.cmi.2015.02.030.
    [24] Anna O, Cornelia S. Candidatus Neoehrlichia mikurensis—recent insights and future perspectives on clinical cases, vectors, and reservoirs in Europe[J]. Curr Clin Microbiol Rep, 2018(5): 1–9. DOI: 10.1007/s40588−018−0085−y.
    [25] Schouls LM, Van De Pol I, Rijpkema SGT, et al. Detection and identification of Ehrlichia, Borrelia burgdorferi sensu lato, and Bartonella species in Dutch Ixodes ricinus ticks[J]. J Clin Microbiol, 1999, 37(7): 2215–2222. DOI: 10.1128/JCM.37.7.2215−2222.1999.
    [26] Pan H, Liu SZ, Ma YH, et al. Ehrlichia-like organism gene found in small mammals in the suburban district of Guangzhou of China.[J]. Ann N Y Acad Sci, 2003, 990(1): 107–111. DOI: 10.1111/j.1749−6632.2003.tb07346.x.
    [27] Kawahara M, Rikihisa Y, Isogai E, et al. Ultrastructure and phylogenetic analysis of “Candidatus Neoehrlichia mikurensis” in the family Anaplasmataceae, isolated from wild rats and found in Ixodes ovatus ticks[J]. Int J Syst Evol Microbiol, 2004, 54(5): 1837–1843. DOI: 10.1099/ijs.0.63260−0.
    [28] Li H, Jiang J, Tang F, et al. Wide distribution and genetic diversity of “Candidatus Neoehrlichia mikurensis” in rodents from China[J]. Appl Environ Microbiol, 2013, 79(3): 1024–1027. DOI: 10.1128/AEM.02917−12.
    [29] 陆群英, 程苏云, 彭伟龙, 等. 浙江省动物米库尔新埃立克体及其16S rRNA基因分析[J]. 中华流行病学杂志,2012,33(9):993–994. DOI:10.3760/cma.j.issn.0254−6450.2012.09.028.

    Lu QY, Cheng SY, Peng WL, et al. Candidatus Neoehrlichia mikurensis infection on animals and related 16S rRNA gene analysis in Zhejiang province[J]. Chin J Epidemi, 2012, 33(9): 993–994. DOI: 10.3760/cma.j.issn.0254−6450.2012.09.028.
    [30] Lu M, Li F, Liao Y, et al. Epidemiology and diversity of Rickettsiales Bacteria in humans and animals in Jiangsu and Jiangxi Provinces, China[J]. Sci Rep, 2019, 9(1): 1–9. DOI: 10.1328/s41598−019−49059−3.
    [31] 王卓, 王建伟, 于淼, 等. 东北边境地区啮齿动物中新埃立克体感染调查及groEL基因序列分析[J]. 中国人兽共患病学报,2019,35(4):330–333. DOI: 10.3969/j.issn.10022694.2019.00.032.

    Wang Z, Wang JW, Yu M, et al. Investigation on Candidatus Neoehrlichia mikurensis in rodents collected in forest area in the northeastern region of China[J]. Chin. J. Zoonoses, 2019, 35(4): 330–333. DOI:  10.3969/j.issn.10022694.2019.00.032.
    [32] 肖方震, 邓艳琴, 林代华, 等. 福建省鼠类携带新埃立克体调查及16S rRNA和groEL基因特征研究[J]. 中国病原生物学杂志,2020,15(4):416–420. DOI: 10.13350/j.cjpb.200410.

    Xiao FZ, Deng YQ, Lin DH, et al. Study of Candidatus Neoehrlichia mikurensis in rodents in Fujian Province and an investigation of the characteristics of its 16S rRNA and groEL genes[J]. J Path Biol, 2020, 15(4): 416–420. DOI:  10.13350/j.cjpb.200410.
    [33] 肖方震, 陈美宝, 韩腾伟, 等. 三明市鼠类携带蜱传病原体的混合感染研究[J]. 中国病原生物学杂志,2019,14(7):811–813. DOI: 10.13350/j.cjpb.190714.

    Xiao FZ, Chen MB, Han TW, et al. Research on coinfection with multiple tick-borne pathogens in rodents in the Sanming region of Fujian Province[J]. J Path Biol, 2019, 14(7): 811–813. DOI:  10.13350/j.cjpb.190714.
    [34] Galfsky D, Krol N, Pfeffer M, et al. Long-term trends of tick-borne pathogens in regard to small mammal and tick populations from Saxony, Germany[J]. Parasites & Vectors, 2019, 12(1): 131. DOI: 10.1186/s13071−019−3382−2.
    [35] Portillo A, Santibáñez P, Palomar AM, et al. “Candidatus Neoehrlichia mikurensis” in Europe[J]. New Microbes New Infect, 2018, 22: 30–36. DOI:  10.1016/j.nmni.2017.12.011.
    [36] Jha P, Kim CM, Kim DM, et al. First detection and identification of Candidatus Neoehrlichia mikurensis in South Korea[J]. PLoS One, 2018, 13(12): e209685. DOI:  10.1371/journal.pone.0209685.
    [37] Obiegala A, Pfeffer M, Pfister K, et al. Candidatus Neoehrlichia mikurensis and Anaplasma phagocytophilum: prevalences and investigations on a new transmission path in small mammals and ixodid ticks.[J]. Parasites & Vectors, 2014, 7(1): 1–10. DOI: 10.1186/s13071−014−0563−x.
    [38] Hofmann-Lehmann R, Wagmann N, Meli M-L, et al. Detection of “Candidatus Neoehrlichia mikurensis” and other Anaplasmataceae and Rickettsiaceae in Canidae in Switzerland and Mediterranean countries.[J]. Schweizer Archiv fur Tierheilkunde, 2016, 158(10): 691–700. DOI:  10.17236/sat00087.
    [39] Václavík T, Balážová A, Baláž V, et al. Landscape epidemiology of neglected tick-borne pathogens in central Europe[J]. Transbound Emerg Dis, 2021, 68(3): 1685–1696. DOI:  10.1111/tbed.13845.
    [40] 洪学庚, 王卓, 冯立, 等. 暂定新埃立克体属研究进展[J]. 中国预防医学杂志,2017,18(12):949–954. DOI:10.16506/j.1009−6639.2017.12.017.

    Hong XG, Wang Z, Feng L, et al. Progress in the study of the tentative Candidates Neoehrlichia[J]. Chin Prev Med, 2017, 18(12): 949–954. DOI: 10.16506/j.1009−6639.2017.12.017.
    [41] Ondruš J, Balážová A, Baláž V, et al, et al. Candidatus Neoehrlichia mikurensis is widespread in questing Ixodes ricinus ticks in the Czech Republic[J]. Ticks Tick Borne Dis, 2020, 11(3): 101371. DOI:  10.1016/j.ttbdis.2020.101371.
    [42] Labbé Sandelin L, Olofsson J, Tolf C, et al. Detection of Neoehrlichia mikurensis DNA in blood donors in southeastern Sweden[J]. Infect Dis (Lond) , 2022, 54(10): 748–759. DOI:  10.1080/23744235.2022.2087732.
    [43] Wennerås C, Goldblatt D, Zancolli M, et al. Natural IgM antibodies in the immune defence against neoehrlichiosis[J]. Infect Dis (Lond) , 2017, 49(11-12): 809–816. DOI:  10.1080/23744235.2017.1347815.
    [44] Höper L, Skoog E, Stenson M, et al. Vasculitis due to Candidatus Neoehrlichia mikurensis: A Cohort Study of 40 Swedish Patients[J]. Clin Infect Dis, 2021, 73(7): 2372–2378. DOI:  10.1093/cid/ciaa1217.
    [45] Wass L, Quarsten H, Lindgren PE, et al. Cytokine responses of immunosuppressed and immunocompetent patients with Neoehrlichia mikurensis infection[J]. Med Microbiol Immunol, 2022, 211(2-3): 133–141. DOI: 10.1007/s00430−022−00737−6.
    [46] Azagi T, Dirks RP, Yebra-Pimentel ES, et al. Assembly and Comparison of Ca. Neoehrlichia mikurensis Genomes[J]. Microorganisms, 2022, 10(6): 1134. DOI:  10.3390/microorganisms10061134.
    [47] Cafiso A, Olivieri E, Floriano AM, et al. Investigation of Tick-Borne Pathogens in Ixodes ricinus in a Peri-Urban Park in Lombardy (Italy) Reveals the Presence of Emerging Pathogens[J]. Pathogens, 2021, 10(6): 732. DOI:  10.3390/pathogens10060732.
    [48] 张萌, 王桐萱, 于志军, 等. 蜱类摘除方法概述[J]. 中国媒介生物学及控制杂志,2021,32(2):243–246. DOI: 10.11853/j.issn.1003.8280.2021.02.025.

    Zang M, Wang TX, Yu ZJ, et al. An overview of tick removal methods[J]. Chin J Vector Biol &Control, 2021, 32(2): 243–246. DOI:  10.11853/j.issn.1003.8280.2021.02.025.
  • 加载中
表(2)
计量
  • 文章访问数:  227
  • HTML全文浏览量:  73
  • PDF下载量:  42
  • 被引次数: 0
出版历程
  • 收稿日期:  2022-06-27
  • 网络出版日期:  2022-11-06
  • 刊出日期:  2022-12-01

目录

    /

    返回文章
    返回

    在线交流

    防诈骗公告

    大家好:近期有不法分子以本刊编辑身份添加作者微信,请务必提高警惕!本刊关于稿件的一切事项通知均采用编辑部唯一邮箱(jbjc@icdc.cn)和座机(010-58900732)联系作者,且在录用稿件后仅收取版面费,无其他任何名目费用(如审稿费和加急费等),非编辑部邮箱发送的本刊收费用通知等均为诈骗,不要随意汇入款项!如有可疑及时致电编辑部核实确认!