Mortality and years of life lost of pancreatic cancer in Huzhou, Zhejiang, 2013–2020
-
摘要:
目的 了解2013 — 2020年浙江省湖州市胰腺癌死亡水平、变化趋势及寿命损失情况，为胰腺癌防治提供依据。 方法 通过浙江省慢性病监测管理系统收集2013 — 2020年湖州市居民胰腺癌死亡资料（ICD-10编码为C25.0～C25.9），运用Excel 2010、SPSS 19.0等软件计算胰腺癌粗死亡率、标化率、潜在减寿年数（PYLL）、潜在工作损失年数（WPYLL）等指标了解胰腺癌死亡水平及对人群健康的影响，组间死亡率的比较采用χ2检验，死亡率随时间变化运用年度变化百分比（APC）进行衡量，采用曲线估计指数分布回归模型计算β，对APC检验采用t检验。 结果 2013 — 2020年湖州市居民胰腺癌累计死亡2 455例，占所有癌症死亡的6.34%，死因顺位保持在第5位，死亡年龄（70.45±10.95）岁，其中年龄最小者为27岁，最长者为97岁。 胰腺癌死亡构成比随时间呈上升趋势（P＜0.05），平均死亡年龄女性大于男性（P＜0.05）。 2013 — 2020年湖州市居民胰腺癌粗死亡率为11.58/10万，标化死亡率为8.02/10万，粗死亡率呈逐年上升趋势（P＜0.05），标化死亡率差异无统计学意义。 男性胰腺癌粗死亡率13.48/10万，高于女性9.68/10万（P＜0.05）。 2013 — 2020年胰腺癌死因顺位保持在第5位，女性死因顺位由2013年的第5位上升至2020年的第4位。 胰腺癌粗死亡率随年龄增长呈上升趋势（P＜0.05），死亡人群集中在45岁以后，在80岁及以上年龄组达到高峰。 2013 — 2020年湖州市各地区死亡率在青、中、老三组居民中呈明显增长的变化，老年组死亡率最高，达50.41/10万。 2013 — 2020年因胰腺癌死亡导致的PYLL为10 002.50人年，WPYLL为 3 903.00人年， PYLL率为0.52‰，WPYLL率为0.20‰，男性PYLL、WPYLL均高于女性。 结论 2013 — 2020年湖州市居民胰腺癌死亡率呈上升趋势，女性死因顺位逐渐靠前，老年人和男性是高危人群，女性死亡率有上升趋势，需引起关注。 加大健康宣传，营造合理膳食、戒烟限酒、适量运动的氛围，从根本上改变不健康的生活方式和饮食结构，做好胰腺癌的一级预防。 Abstract:Objective To investigate the mortality and years of life lost of pancreatic cancer in Huzhou, Zhejiang province, from 2013 to 2020, and provide scientific evidence for the prevention and control of pancreatic cancer in the future. Methods The death surveillance data in Huzhou from 2013 to 2020 were collected from Zhejiang Chronic Disease Surveillance Information Management System (ICD-10 code C25.0–C25.9), the crude mortality, standardized mortality, potential years of life lost (PYLL), working potential years of life lost (WPYLL) were calculated to understand the death level of pancreatic cancer and its effect on population health, the annual percentage change (APC) was used to analyze the trend of pancreatic cancer death. Results From 2013 to 2020, a total of 2 455 deaths of pancreatic cancer were reported in Huzhou, accounting for 6.34% of all cancer deaths, the average age of the death cases was (70.45±10.95) years. The youngest was 27 years old and the oldest was 97 years old. The death component ratio of pancreatic cancer increased with time (P＜0.05), and the average death age of women was higher than that of men (P＜0.05). From 2013 to 2020, the crude mortality and the standardized mortality of pancreatic cancer in residents in Huzhou were 11.58/100 000 and 8.02/100 000. The crude mortality showed an upward trend (P＜0.05), but the difference in standardized mortality of pancreatic cancer had no significant difference. The crude mortality of pancreatic cancer was 13.48/100 000 in men and 9.68/100 000 in women, and the difference was significant (P＜0.05). Pancreatic cancer ranked fifth of death causes, but the ranking in women rose from fifth in 2013 to fourth in 2020. The crude mortality rate of pancreatic cancer increased with age (P＜0.05）. The deaths mainly occurred after the age of 45 years and peaked in age group 80-years. From 2013 to 2020, the mortality rate in the three groups (young, middle aged and old) of residents in Huzhou showed a significant increase. The mortality rate in the elderly group was highest, reaching 50.41/100 000. The PYLL and WPYLL caused by pancreatic cancer death were 10 002.50 and 3 903 person-years, the rates of PYLL and WPYLL were 0.52‰ and 0.20‰. The PYLL and WPYLL were higher in men than in women. Conclusion The mortality rate of pancreatic cancer in Huzhou showed an increasing trend from 2013 to 2020. The ranking of pancreatic cancer in death causes in women moved ahead, and the elderly and men were the high-risk groups, the mortality rate in women showed an upward trend, to which close attention needs to paid. It is necessary to strengthen the health education about healthy life style, rational diet, limited smoking and alcohol, moderate exercise for the primary prevention of pancreatic cancer. -
Key words:
- Pancreatic cancer /
- Mortality /
- Annual percentage change /
- Years of life lost
-
表 1 2013－2020年湖州市居民胰腺癌死亡构成分布
Table 1. Death composition of pancreatic cancer in Huzhou, 2013–2020
年份 男性 女性 合计 构成比
（%）顺位 构成比
（%）顺位 构成比
（%）顺位 2013 4.66 5 7.44 5 5.61 5 2014 5.28 6 6.46 5 5.68 5 2015 4.71 6 7.78 5 5.70 5 2016 4.95 6 7.95 5 5.93 5 2017 5.97 6 6.89 5 6.28 5 2018 6.01 6 8.48 5 6.84 5 2019 6.14 5 8.76 4 7.03 5 2020 6.50 5 9.03 4 7.37 5 年平均值 5.55 6 7.89 5 6.34 5 APC（%） 4.917 − 3.666 − 4.393 − t值 4.936 − 2.759 − 9.759 − P值 0.003 − 0.033 − ＜0.001 − 
下载: 导出CSV
表 2 2013－2020年湖州市居民胰腺癌死亡平均年龄分布
Table 2. Average age distribution of pancreatic cancer in Huzhou, 2013–2020
年份 总计（岁） 男性（岁） 女性（岁） P值 2013 68.92±11.33 67.97±10.90 70.07±11.77 0.136 2014 70.04±10.63 69.87±10.81 70.32±10.38 0.741 2015 69.79±10.97 68.87±10.88 70.97±11.02 0.118 2016 70.42±11.07 70.15±11.04 70.76±11.13 0.644 2017 69.62±11.45 68.58±11.45 71.34±11.28 0.044 2018 69.93±10.43 69.93±10.43 72.38±10.29 0.035 2019 71.79±10.93 70.92±10.74 72.97±11.12 0.078 2020 71.19±10.55 69.83±10.63 73.05±10.18 0.003 合计 70.45±10.95 69.59±10.90 71.64±10.90 ＜0.001
下载: 导出CSV
表 3 2013－2020年湖州市居民胰腺癌死亡率变化趋势
Table 3. Trend of mortality of pancreatic cancer in Huzhou, 2013–2020
年份 男性（/10万） 女性（/10万） 合计（/10万） 粗死亡
率标化
死亡率粗死亡
率标化
死亡率粗死亡
率标化
死亡率2013 10.69 8.81 8.96 7.74 9.83 8.28 2014 12.06 9.62 7.70 6.57 9.88 8.19 2015 11.46 8.78 8.95 7.18 10.20 8.01 2016 11.95 8.86 9.32 7.19 10.63 8.04 2017 13.95 10.58 8.38 6.44 11.16 8.55 2018 14.58 10.31 10.36 7.69 12.46 9.03 2019 15.92 8.18 11.37 6.05 13.61 7.14 2020 17.27 8.83 12.29 6.46 14.75 7.67 年平均值 13.48 9.13 9.68 6.85 11.58 8.02 APC（%） 6.93 −0.20 5.44 −1.88 6.29 −0.10 t值 8.985 −0.109 3.696 −1.457 9.001 −0.865 P值 ＜0.001 0.917 0.010 0.195 ＜0.001 0.420
下载: 导出CSV
表 4 2013－2020年湖州市居民胰腺癌年龄别死亡率变化趋势
Table 4. Age-specific mortality of pancreatic cancer in Huzhou, 2013–2020
年龄组
（岁）死亡率（/10万） 男性 女性 合计 25～ 0.00 0.14 0.07 30～ 0.13 0.00 0.07 35～ 0.86 0.12 0.48 40～ 1.34 0.80 1.07 45～ 3.20 1.93 2.57 50～ 9.76 6.65 8.25 55～ 14.93 7.18 11.11 60～ 27.90 19.24 23.64 65～ 50.93 35.80 43.27 70～ 68.18 39.58 53.67 75～ 77.08 56.56 66.45 80～ 115.74 90.15 101.96 85～ 120.02 89.43 101.92 趋势χ2值 2608.08 2090.83 4666.95 P值 ＜0.001 ＜0.001 ＜0.001
下载: 导出CSV
表 5 2013－2020年湖州市各地区胰腺癌年龄别死亡率变化趋势
Table 5. Age-specific mortality of pancreatic cancer in different areas of Huzhou, 2013–2020
地区 年龄组
（岁）死亡率（/10万） APC（%） t值 P值 2013年 2014年 2015年 2016年 2017年 2018年 2019年 2020年 合计 吴兴区 ＜45 0.74 0.52 0.26 0.00 0.00 0.00 0.28 0.00 0.23 −8.15 −2.686 0.036 45～ 12.34 3.82 7.61 9.84 10.53 8.22 6.07 12.39 8.93 3.15 0.483 0.646 ≥60 56.24 61.69 58.07 62.04 50.42 73.49 61.31 50.27 58.48 0.40 −0.184 0.860 南浔区 ＜45 0.68 0.00 0.37 0.38 0.00 0.00 0.00 0.50 0.24 −3.25 −0.748 0.483 45～ 5.97 9.02 7.88 6.32 9.47 7.08 6.09 5.93 7.21 −2.27 −0.762 0.475 ≥60 47.61 51.04 60.01 52.93 41.47 56.90 56.05 47.42 51.63 0.00 0.022 0.983 德清县 ＜45 0.00 0.00 0.00 0.00 0.86 0.00 0.00 0.50 0.16 7.47 1.566 0.168 45～ 1.93 6.74 6.01 9.00 8.69 6.93 3.47 4.00 5.81 2.63 0.296 0.777 ≥60 44.06 49.51 47.54 43.99 48.22 53.52 50.64 52.23 49.01 2.12 2.441 0.050 长兴县 ＜45 0.26 0.00 0.26 0.00 0.52 0.52 0.29 0.00 0.24 1.11 0.307 0.769 45～ 3.37 4.75 6.08 5.46 5.45 6.79 4.88 11.01 6.10 10.96 2.798 0.031 ≥60 49.35 42.42 42.26 52.60 57.50 65.14 55.08 42.81 50.53 2.02 0.793 0.458 安吉县 ＜45 0.72 0.00 0.00 1.17 0.86 0.00 0.44 0.45 0.45 0.00 0.000 1.000 45～ 10.57 9.65 4.45 4.93 4.51 8.94 8.10 5.11 6.99 −4.59 −0.808 0.450 ≥60 55.30 56.46 45.13 39.81 50.53 40.19 51.01 44.51 47.38 −2.47 −1.272 0.250 湖州市 ＜45 0.49 0.13 0.19 0.26 0.39 0.13 0.24 0.24 0.26 −3.15 −0.409 0.696 45～ 6.93 6.63 6.47 7.02 7.76 7.60 5.39 8.11 6.99 0.80 0.364 0.729 ≥60 50.67 51.84 50.72 50.43 51.87 57.37 46.60 47.15 50.41 −0.80 −0.745 0.484
下载: 导出CSV
表 6 2013－2020年湖州市居民胰腺癌死亡潜在寿命损失情况
Table 6. Potential loss of life due to pancreatic cancer in Huzhou, 2013–2020
年份 男性 女性 总计 潜在减
寿年数
（人年）潜在减寿
年数率
（‰）潜在工作
损失年
（人年）潜在工作
损失年率
（‰）潜在减寿
年数
（人年）潜在减寿
年数率
（‰）潜在工作
损失年
（人年）潜在工作
损失年率
（‰）潜在减
寿年数
（人年）潜在减寿
年数率
（‰）潜在工作
损失年
（人年）潜在工作
损失年率
（‰）2013 755.00 0.61 326.00 0.13 537.50 0.44 257.00 0.11 1 292.50 0.53 583.00 0.24 2014 685.00 0.57 311.00 0.13 397.50 0.33 117.00 0.05 1 082.50 0.45 428.00 0.18 2015 727.50 0.61 304.00 0.13 447.50 0.37 145.00 0.06 1 175.00 0.49 449.00 0.19 2016 662.50 0.55 283.00 0.12 515.00 0.43 196.00 0.08 1 177.50 0.49 479.00 0.20 2017 965.00 0.80 448.00 0.19 442.50 0.37 162.00 0.07 1 407.50 0.58 610.00 0.25 2018 805.00 0.67 266.00 0.11 430.00 0.36 155.00 0.06 1 235.00 0.51 421.00 0.17 2019 757.50 0.64 268.00 0.11 482.50 0.41 180.00 0.08 1 240.00 0.53 448.00 0.19 2020 930.00 0.79 358.00 0.15 462.50 0.39 127.00 0.05 1 392.50 0.60 485.00 0.21 合计 6287.50 0.66 2564.00 0.13 3715.00 0.39 1 339.00 0.07 10 002.50 0.52 3 903.00 0.20 APC（%） − 3.67 − 0.10 − 0.00 − −3.82 − 2.43 − −0.90 t值 − 2.030 − 0.050 − 0.006 − −0.940 − 1.909 − −0.416 P值 − 0.089 − 0.962 − 0.995 − 0.383 − 0.105 − 0.692
下载: 导出CSV
-
[1] Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020[J]. CA Cancer J Clin, 2020, 70(1): 7–30. DOI: 10.3322/caac.21590. [2] 浙江省疾病预防控制中心. 2020年度浙江省居民死因慢性病伤害监测年度报告［M］. 杭州: 浙江省疾病预防控制中心, 2021: 19–24.Zhejiang Provincial Center for Disease Control and Prevention. Annual report on chronic disease injury surveillance of death causes among residents in Zhejiang province in 2020［M］. Hangzhou: Zhejiang Provincial Center for Disease Control and prevention, 2021: 19–24. [3] Zeng H, Zheng R, Guo Y, et al. Cancer survival in China, 2003–2005: a population-based study[J]. Int J Cancer, 2015, 136(8): 1921–1930. DOI: 10.1002/ijc.29227. [4] 北京协和医院世界卫生组织国际分类家族合作中心. 疾病和有关健康问题的国际统计分类（第十次修订本）［M］. 董景五, 译. 2版. 北京: 人民卫生出版社, 1997: 152–153.WHO International Classification Family Cooperation Center of Peking Union Medical College Hospital. International statistical classification of diseases and related health problems (tenth revision)［M］// Dong JW, 2nd ed. Beijing: People′s Medical Publishing House, 1997: 152–153. [5] 杨梨丽, 林启, 王玉超, 等. 舟山市居民溺水死亡及潜在寿命损失分析[J]. 预防医学,2019,31(11):1116–1119. DOI:10.19485/j.cnki.issn2096−5087.2019.11.009.Yang LL, Lin Q, Wang YC, et al. Mortality and potential life lost of drowning in Zhoushan residents[J]. Prev Med, 2019, 31(11): 1116–1119. DOI: 10.19485/j.cnki.issn2096−5087.2019.11.009. [6] 沈永洲, 杜灵彬, 汪祥辉, 等. 浙江省肿瘤登记地区2000-2009年胰腺癌流行趋势分析[J]. 中国卫生统计,2015,32(1):101–103.Shen YZ, Du LB, Wang XH, et al. Analysis of the epidemic trend of pancreatic cancer in Zhejiang cancer registry area in 2000–2009 years[J]. Chin J Health Statist, 2015, 32(1): 101–103. [7] 陈竺. 全国第三次死因回顾抽样调查报告［M］. 北京: 中国协和医科大学出版社, 2008: 37–38.Chen Z. Report of the third national retrospective sampling survey on causes of death［M］. Beijing: China Union Medical University Press, 2008: 37–38. [8] Huang JJ, Lok V, Ho Ngai C, et al. Worldwide burden of, risk factors for, and trends in pancreatic Cancer[J]. Gastroenterology, 2021, 160(3): 744–754. DOI: 10.1053/j.gastro.2020.10.007. [9] 纪威, 张良, 应焱燕, 等. 2010-2018年宁波市胰腺癌发病和死亡趋势分析[J]. 预防医学,2020,32(8):805–807. DOI:10.19485/j.cnki.issn2096−5087.2020.08.011.Ji W, Zhang L, Ying YY, et al. Analysis of incidence and mortality trend of pancreatic cancer in Ningbo in 2010–2018 years[J]. Prev Med, 2020, 32(8): 805–807. DOI: 10.19485/j.cnki.issn2096−5087.2020.08.011. [10] 梁智恒, 李柱明, 魏矿荣. 1970-2015年广东省中山市胰腺癌发病与死亡分析[J]. 中国肿瘤,2020,29(10):751–757. DOI:10.11735/j.issn.1004−0242.2020.10.A006.Liang ZH, Li ZM, Wei KR. Incidence and mortality of pancreatic cancer in Zhongshan city of Guangdong province, 1970–2015[J]. Chin Tumor, 2020, 29(10): 751–757. DOI: 10.11735/j.issn.1004−0242.2020.10.A006. [11] 田明, 严俊, 胡进静, 等. 胰腺癌流行现状及危险因素综述[J]. 中国社会医学杂志,2016,33(2):137–139. DOI:10.3969/j.issn.1673−5625.2016.02.012.Tian M, Yan J, Hu JJ, et al. Review of the prevalence situation and the risk factors of pancreatic cancer[J]. Chin J Soc Med, 2016, 33(2): 137–139. DOI: 10.3969/j.issn.1673−5625.2016.02.012. [12] 李光琳, 陈万青, 王庆生, 等. 胰腺癌死亡率与糖尿病患病率的关系[J]. 肿瘤预防与治疗,2010,23(2):132–136. DOI:10.3969/j.issn.1674−0904.2010.02.011.Li GL, Chen WQ, Wang QS, et al. Analysis of the association between pancreas cancer and diabetes[J]. J Cancer Control Treat, 2010, 23(2): 132–136. DOI: 10.3969/j.issn.1674−0904.2010.02.011. [13] 赫捷, 陈万青. 2017中国肿瘤登记年报［M］. 北京: 人民卫生出版社, 2018: 117–121.He J, Chen WQ. 2017 China cancer registry annual report［M］. Beijing: People′s Medical Publishing House, 2018: 117–121. [14] 李伟伟, 董建梅, 秦绪成, 等. 连云港市2007-2012年胰腺癌发病特征及趋势[J]. 江苏预防医学,2017,28(5):509–511. DOI:10.13668/j.issn.1006−9070.2017.05.09.Li WW, Dong JM, Qin XC, et al. Epidemiological characteristics and trend of pancreatic cancer in Lianyungang city from 2007 to 2012[J]. Jiangsu J Prev Med, 2017, 28(5): 509–511. DOI: 10.13668/j.issn.1006−9070.2017.05.09. [15] Koyanagi YN, Ito H, Matsuo K, et al. Smoking and pancreatic cancer incidence: a pooled analysis of 10 population-based cohort studies in Japan[J]. Cancer Epidemiol Biomarkers Prev, 2019, 28(8): 1370–1378. DOI: 10.1158/1055−9965.EPI−18−1327. [16] Michaud DS, Skinner HG, Wu KN, et al. Dietary patterns and pancreatic cancer risk in men and women[J]. J Natl Cancer Inst, 2005, 97(7): 518–524. DOI: 10.1093/jnci/dji094. [17] Ji BT, Hatch MC, Chow WH, et al. Anthropometric and reproductive factors and the risk of pancreatic cancer: a case-control study in Shanghai, China[J]. Int J Cancer, 1996, 66(4): 432–437. DOI: 10.1002/(SICI)1097−0215(19960516)66:4<432::AID−IJC4>3.0.CO;2−X. -
点击查看大图
表(6)
计量
- 文章访问数: 321
- HTML全文浏览量: 199
- PDF下载量: 25
- 被引次数: 0