2018-2020年浙江省舟山市蜱类分布及发热伴血小板减少综合征病例调查

刘洁楠 李天奇 李科峰 戴亚欣

刘洁楠, 李天奇, 李科峰, 戴亚欣. 2018-2020年浙江省舟山市蜱类分布及发热伴血小板减少综合征病例调查[J]. 疾病监测, 2021, 36(9): 920-925. doi: 10.3784/jbjc.202106200346
引用本文: 刘洁楠, 李天奇, 李科峰, 戴亚欣. 2018-2020年浙江省舟山市蜱类分布及发热伴血小板减少综合征病例调查[J]. 疾病监测, 2021, 36(9): 920-925. doi: 10.3784/jbjc.202106200346
Liu Jienan, Li Tianqi, Li Kefeng, Dai Yaxin. Survey of ticks and severe fever with thrombocytopenia syndrome in Zhoushan, Zhejiang, 2018–2020[J]. Disease Surveillance, 2021, 36(9): 920-925. doi: 10.3784/jbjc.202106200346
Citation: Liu Jienan, Li Tianqi, Li Kefeng, Dai Yaxin. Survey of ticks and severe fever with thrombocytopenia syndrome in Zhoushan, Zhejiang, 2018–2020[J]. Disease Surveillance, 2021, 36(9): 920-925. doi: 10.3784/jbjc.202106200346

2018-2020年浙江省舟山市蜱类分布及发热伴血小板减少综合征病例调查

doi: 10.3784/jbjc.202106200346
详细信息
    作者简介:

    刘洁楠,女,浙江省舟山市人,硕士,主管医师,主要从事传染病防控及病媒生物监测工作,Email:86550691@qq.com

    李天奇,男,浙江省杭州市人,博士,主管技师,主要从事病媒生物防制工作,Email:tqli@cdc.zj.cn

    通讯作者:

    李科峰,Tel:0580–2080916,Email:107923738@qq.com

  • 中图分类号: R211;R384

Survey of ticks and severe fever with thrombocytopenia syndrome in Zhoushan, Zhejiang, 2018–2020

More Information
  • 摘要:   目的   了解浙江省舟山市蜱类季节消长规律、种群分布情况及发热伴血小板减少综合征病例发生情况,分析其相关性。  方法   2018 — 2020年在舟山市定海、普陀、岱山、嵊泗区(县)发热伴血小板减少综合征确诊病例发生地周围采用布旗法收集游离蜱,采用体表检蜱法收集寄生蜱,运用荧光反转录酶聚合酶链式反应(RT-PCR)检测新型布尼亚病毒核酸。采用Excel 2017软件汇总数据,用SPSS 19.0 软件进行数据分析。  结果  2018 — 2020年共捕获游离蜱612只,以长角血蜱为主(83.82%),镰形扇头蜱次之(14.05%)。 共有发热伴血小板减少综合征病例20例,发病基本集中在岱山县。 在确诊病例发生地周围共捕获51只游离蜱,86只寄生蜱,均为长角血蜱,经检测新型布尼亚病毒核酸均为阴性。  结论  舟山市优势蜱种为长角血蜱,农村外环境是蜱的主要生活环境,每年5 — 9月是蜱的活动高峰时间,发热伴血小板减少综合征病例的发生与蜱的活动高峰密切相关。
  • 图  1  浙江省舟山市各县(区)游离蜱密度月份分布

    Figure  1.  Monthly free tick density in different counties in Zhoushan

    图  2  浙江省舟山市不同蜱种游离蜱密度月份分布

    Figure  2.  Species specific free tick density in different months in Zhoushan

    图  3  2018-2020年浙江省舟山市蜱密度与发热伴血小板减少综合征发病相关性

    Figure  3.  Association between tick density and SFTS incidence in Zhoushan, 2018–2020

    表  1  新型布尼亚病毒荧光定量RT-PCR检测引物探针序列

    Table  1.   Detection primer probe sequence of fluorescence quantitative RT-PCR for SFTSV

    引物探针
     名称
    碱基序列(5′~3′)靶标基因产物长度(bp)登录号
    SFTSV-NFGGGTCCCTGAAGGA
    GTTGTAAA
    SFTSV-SAB678789
    SFTSV-NRTGCCTTCACCAAG
    ACTATCAATGT
    SFTSV-SAB678789
    SFTSV-NPFAM-TTCTGTCTTGCTG
    GCTCCGCGC -TAMRA
    SFTSV-S74AB678789
    下载: 导出CSV

    表  2  2018-2020年浙江省舟山市游离蜱捕获情况

    Table  2.   Free ticks captured in Zhoushan, 2018–2020

    年份捕获
    游离
    蜱数
    (只)
    拖蜱
    距离
    (m)
    蜱密度[只/
    (布旗·
    100 m)]
    长角
    血蜱
    (只)
    中华
    硬蜱
    (只)
    镰形扇
    头蜱
    (只)
    其他
    (只)
    2018220 40 0000.55211 4 50
    2019199 39 0200.51125 6653
    2020193 35 7400.54177 0160
    合计6121147600.5351310863
    下载: 导出CSV

    表  3  2018-2020年发热伴血小板减少综合征病例发生地游离蜱捕获情况

    Table  3.   Free ticks captured in areas with SFTS cases, 2018–2020

    年份捕获游离蜱数(只)拖蜱距离(m)蜱密度[只/(布旗·100 m)]长角
    血蜱
    (只)
    中华
    硬蜱
    (只)
    镰形扇头蜱(只)其他(只)
    201828 4 5000.6228000
    2019 4 1 5000.27 4000
    202019 4 0000.4819000
    合计5110 0000.5151000
    下载: 导出CSV

    表  4  2018-2020年发热伴血小板减少综合征病例发生地寄生蜱捕获情况

    Table  4.   Parasitic ticks captured in areas with SFTS cases, 2018–2020

    年份总计
    动物数量(只)蜱指数动物数量(只)蜱指数动物数量(只)蜱指数
    2018106.30 20.00 125.25
    2019 00.0010.00 10.00
    2020 43.5019.00 54.60
    合计145.5042.25184.78
    下载: 导出CSV

    表  5  2018-2020年舟山市发热伴血小板减少综合征病例流行病学调查情况

    Table  5.   Epidemiological characteristics of SFTS cases in Zhoushan, 2018–2020

     调查情况因素病例数/
    总病例数
    基本情况 家务待业11/20
    农民 6/20
    有基础疾病11/20
    有过敏史 2/20
    危险因素调查 明确被蜱叮咬 2/20
    有家养动物暴露 4/20
    有野生动物暴露 3/20
    有鼠类暴露 5/20
    有田间/菜地劳作史17/20
    有上山活动史 6/20
    房屋周围有杂草/农作物/菜地14/20
    工作/活动区周围有杂草/农作物/菜地12/20
    居住地有蜱 6/20
    下载: 导出CSV
  • [1] Sonenshine DE, Mather TN. Ecological dynamics of tick-borne zoonoses[M]. Oxford: Oxford University Press, 1994: 447.
    [2] Rodino KG, Theel ES, Pritt BS. Tick-borne diseases in the United States[J]. Clin Chem, 2020, 66(4): 537–548. DOI:  10.1093/clinchem/hvaa040.
    [3] Yu XJ, Liang MF, Zhang SY, et al. Fever with thrombocytopenia associated with a novel bunyavirus in China[J]. N Engl J Med, 2011, 364(16): 1523–1532. DOI:  10.1056/NEJMoa1010095.
    [4] Denic S, Janbeih J, Nair S, et al. Acute thrombocytopenia, leucopenia, and Multiorgan dysfunction: the first case of SFTS bunyavirus outside China?[J]. Case Rep Infect Dis, 2011, 2011: 204056. DOI:  10.1155/2011/204056.
    [5] Kim KH, Yi J, Kim G, et al. Severe fever with thrombocytopenia syndrome, South Korea, 2012[J]. Emerg Infect Dis, 2013, 19(11): 1892–1894. DOI:  10.3201/EID1911.130792.
    [6] Takahashi T, Maeda K, Suzuki T, et al. The first identification and retrospective study of severe fever with thrombocytopenia Syndrome in Japan[J]. J Infect Dis, 2014, 209(6): 816–827. DOI:  10.1093/infdis/jit603.
    [7] Shin J, Kwon D, Youn SK, et al. Characteristics and factors associated with death among patients hospitalized for severe fever with thrombocytopenia syndrome, South Korea, 2013[J]. Emerg Infect Dis, 2015, 21(10): 1704–1710. DOI:  10.3201/eid2110.141928.
    [8] Hu JH, Li SY, Zhang X, et al. Correlations between clinical features and death in patients with severe fever with thrombocytopenia syndrome[J]. Medicine (Baltimore) , 2018, 97(22): e10848. DOI:  10.1097/MD.0000000000010848.
    [9] 王建跃, 邬辉, 仝振东, 等. 发热伴血小板减少综合征流行病学研究进展[J]. 中华流行病学杂志,2016,37(2):294–298. DOI:10.3760/cma.j.issn.0254−6450.2016.02.029.

    Wang JY, Wu H, Tong ZD, et al. A review on the epidemiologic features of severe fever with thrombocytopenia syndrome[J]. Chin J Epidemiol, 2016, 37(2): 294–298. DOI: 10.3760/cma.j.issn.0254−6450.2016.02.029.
    [10] 姜晓林, 王显军, 李建东, 等. 家养动物体表蜱中发热伴血小板减少综合征布尼亚病毒分离及鉴定[J]. 病毒学报,2012,28(3):252–257. DOI: 10.13242/j.cnki.bingduxuebao.002273.

    Jiang XL, Wang XJ, Li JD, et al. Isolation, identification and characterization of SFTS bunyavirus from ticks collected on the surface of domestic animals[J]. Chin J Virol, 2012, 28(3): 252–257. DOI:  10.13242/j.cnki.bingduxuebao.002273.
    [11] Li ML, Li Z, Hong LW, et al. Haemaphysalis longicornis ticks as reservoir and vector of severe fever with thrombocytopenia syndrome virus in China[J]. Emerg Infect Dis, 2015, 21(10): 1770–1776. DOI:  10.3201/eid2110.150126.
    [12] Niu GY, Li JD, Liang MF, et al. Severe fever with thrombocytopenia syndrome virus among domesticated animals, China[J]. Emerg Infect Dis, 2013, 19(5): 756–763. DOI:  10.3201/eid1905.120245.
    [13] Wang SW, Li JD, Niu GY, et al. SFTS virus in ticks in an endemic area of China[J]. Am J Trop Med Hyg, 2015, 92(4): 684–689. DOI: 10.4269/ajtmh.14−0008.
    [14] 中华人民共和国卫生部. 发热伴血小板减少综合征防治指南(2010版)[J]. 中华临床感染病杂志,2011,4(4):193–194. DOI:10.3760/cma.j.issn.1674−2397.2011.04.001.

    Ministry of Health of the People's Republic of China. Guideline for prevention and treatment of sever fever with thrombocytopenia syndrome (2010)[J]. Chin J Clin Infect Dis, 2011, 4(4): 193–194. DOI: 10.3760/cma.j.issn.1674−2397.2011.04.001.
    [15] 中华人民共和国国家卫生和计划生育委员会. 全国病媒生物监测方案[S]. 北京: 中国疾病预防控制中心, 2016.

    Health and Family Planning Commission of the People's Republic of China. National vector surveillance program[S]. Beijing: Chinese Center for Disease Control and Prevention, 2016.
    [16] 邓国藩, 姜在阶. 中国经济昆虫志•第三十九册–蜱螨亚纲–硬蜱科[M]. 北京: 科学出版社, 1991: 43–349.

    Deng GF, Jiang ZJ. Economic insect fauna of China. Fasc. 39(Acari: Ixodidae)[M]. Beijing: Science Press, 1991: 43–349.
    [17] Fu YF, Li SB, Zhang Z, et al. Phylogeographic analysis of severe fever with thrombocytopenia syndrome virus from Zhoushan Islands, China: implication for transmission across the ocean[J]. Sci Rep, 2016, 6: 19563. DOI:  10.1038/srep19563.
    [18] 吴海霞, 刘小波, 岳玉娟, 等. 2019年全国蜱类监测报告[J]. 中国媒介生物学及控制杂志,2020,31(4):417–422. DOI: 10.11853/j.issn.1003.8280.2020.04.007.

    Wu HX, Liu XB, Yue YJ, et al. National surveillance report on ticks in China, 2019[J]. Chin J Vector Biol Control, 2020, 31(4): 417–422. DOI:  10.11853/j.issn.1003.8280.2020.04.007.
    [19] 孙毅, 许荣满, 葛学峰, 等. 安徽黄山地区中华硬蜱及其宿主感染莱姆病Borrelia afzelii的检测[J]. 寄生虫与医学昆虫学报,2009,16(3):141–146. DOI:10.3969/j.issn.1005−0507.2009.03.003.

    Sun Y, Xu RM, Ge XF, et al. Natural infection of Borrelia afzelii in Ixodes sinensis and its parasitism hosts in forest areas of Huangshan, Anhui province[J]. Acta Parasitol Med Entomol Sin, 2009, 16(3): 141–146. DOI: 10.3969/j.issn.1005−0507.2009.03.003.
    [20] 罗丽梅. 新布尼亚病毒传播媒介、宿主和蜱传疾病的人群血清流行病学研究[D]. 济南: 山东大学, 2016.

    Luo LM. Investigation of reservoir and vector of severe fever with Thrombocytopenia virus and seroepidemiology of tick-borne diseases in China[D]. Ji′nan: Shandong University, 2016.
    [21] 师佳佳, 吕明洁, 袁中良. 郑州市蜱类地理分布、寄生宿主及季节消长调查[J]. 中国媒介生物学及控制杂志,2021,32(3):361–364. DOI: 10.11853/j.issn.1003.8280.2021.03.020.

    Shi JJ, Lyu MJ, Yuan ZL. An investigation of geographical distribution, host, and seasonality of ticks in Zhengzhou, China[J]. Chin J Vector Biol Control, 2021, 32(3): 361–364. DOI:  10.11853/j.issn.1003.8280.2021.03.020.
    [22] 朱曦, 杨春江, 周元庆. 舟山海岛冬季鸟类研究[J]. 动物学杂志,1991,26(1):35–39, 56.

    Zhu X, Yang CJ, Zhou YQ. Study on winter birds in Zhoushan[J]. Chin J Zool, 1991, 26(1): 35–39, 56.
    [23] 戴亚欣, 李科峰, 李鹏, 等. 舟山市枸杞岛一起家庭聚集性发热伴血小板减少综合征疫情调查[J]. 中国媒介生物学及控制杂志,2018,29(2):181–183. DOI: 10.11853/j.issn.1003.8280.2018.02.017.

    Dai YX, Li KF, Li P, et al. Epidemiological investigation of a family cluster of two patients with severe fever with thrombocytopenia syndrome in Gouqi island of Zhoushan city, Zhejiang province[J]. Chin J Vector Biol Control, 2018, 29(2): 181–183. DOI:  10.11853/j.issn.1003.8280.2018.02.017.
    [24] 严剑波, 仝振东, 唐安, 等. 舟山市发热伴血小板减少综合征流行特征及危险因素研究[J]. 预防医学,2017,29(1):1–10. DOI:10.19485/j.cnki.issn1007−0931.2017.01.001.

    Yan JB, Tong ZD, Tang A, et al. A study on the epidemiological characteristics and risk factors of severe fever with thrombocytopenia syndrome in Zhoushan city[J]. Prev Med, 2017, 29(1): 1–10. DOI: 10.19485/j.cnki.issn1007−0931.2017.01.001.
    [25] 王秋景, 李世波, 叶凌, 等. 2011-2018年舟山海岛岱山县新型布尼亚病毒相关病媒生物监测及防控策略研究[J]. 上海预防医学,2020,32(6):521–526. DOI: 10.19428/j.cnki.sjpm.2020.20074.

    Wang QJ, Li SB, Ye L, et al. Vector biological monitoring and strategy to prevent and control severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) in Daishan country Zhoushan islands 2011–2018[J]. Shanghai Prev Med, 2020, 32(6): 521–526. DOI:  10.19428/j.cnki.sjpm.2020.20074.
    [26] 叶凌, 任宜, 王忠发, 等. 舟山海岛地区2011-2012年新型布尼亚病毒感染监测分析[J]. 中国媒介生物学及控制杂志,2013,24(5):429–431. DOI: 10.11853/j.issn.1003.4692.2013.05.014.

    Ye L, Ren Y, Wang ZF, et al. Surveillance and analysis of new Bunia virus infections in Zhoushan Island area during 2011–2012[J]. Chin J Vector Biol Control, 2013, 24(5): 429–431. DOI:  10.11853/j.issn.1003.4692.2013.05.014.
  • 2021-0346_f2018-2020年浙江省舟山市蜱类分布及发热伴血小板减少综合征病例调查.doc
  • 加载中
图(3) / 表(5)
计量
  • 文章访问数:  107
  • HTML全文浏览量:  71
  • PDF下载量:  6
  • 被引次数: 0
出版历程
  • 收稿日期:  2021-06-20
  • 网络出版日期:  2021-09-17
  • 刊出日期:  2021-09-30

目录

    /

    返回文章
    返回

    在线交流

    防诈骗公告

    近期有不法分子以本刊编辑身份添加作者微信,请务必提高警惕!本刊关于稿件的一切事项通知均采用编辑部唯一邮箱(jbjc@icdc.cn)和座机(010-58900732)联系作者,且在录用稿件后仅收取版面费,无其他任何名目费用(如审稿费和加急费等),非编辑部邮箱发送的本刊收费用通知等均为诈骗,不要随意汇入款项!如有可疑及时致电编辑部核实确认!