Abstract: Rotavirus is the most important pathogen of intestinal infections in children, often causing gastrointestinal symptoms. Rotavirus infects the brain, liver, lungs, heart, kidneys and other organs, causing a series of systemic diseases, through viremia and possible respiratory transmission. However, the mechanism of extra-intestinal infection is not yet clear, further study is still needed. This paper summarizes the pathogenesis, laboratory diagnosis and clinical manifestations of central nervous system damage, liver damage, type 1 diabetes, respiratory system damage and heart damage caused by extra intestinal infection of rotavirus to provide help for the exploration of the mechanism of extra-intestinal infection of rotavirus.