2016-2019年我国诺如病毒暴发疫情的分子流行病学特征分析

朱曦 孔翔羽 章青 李静欣 李慧莹 靳淼 段招军

朱曦, 孔翔羽, 章青, 李静欣, 李慧莹, 靳淼, 段招军. 2016-2019年我国诺如病毒暴发疫情的分子流行病学特征分析[J]. 疾病监测, 2021, 36(8): 774-779. doi: 10.3784/jbjc.202106240363
引用本文: 朱曦, 孔翔羽, 章青, 李静欣, 李慧莹, 靳淼, 段招军. 2016-2019年我国诺如病毒暴发疫情的分子流行病学特征分析[J]. 疾病监测, 2021, 36(8): 774-779. doi: 10.3784/jbjc.202106240363
Zhu Xi, Kong Xiangyu, Zhang Qing, Li Jingxin, Li Huiying, Jin Miao, Duan Zhaojun. Molecular epidemiological characteristics of norovirus outbreaks reported to Chinese norovirus outbreak laboratory surveillance network, 2016–2019[J]. Disease Surveillance, 2021, 36(8): 774-779. doi: 10.3784/jbjc.202106240363
Citation: Zhu Xi, Kong Xiangyu, Zhang Qing, Li Jingxin, Li Huiying, Jin Miao, Duan Zhaojun. Molecular epidemiological characteristics of norovirus outbreaks reported to Chinese norovirus outbreak laboratory surveillance network, 2016–2019[J]. Disease Surveillance, 2021, 36(8): 774-779. doi: 10.3784/jbjc.202106240363

2016-2019年我国诺如病毒暴发疫情的分子流行病学特征分析

doi: 10.3784/jbjc.202106240363
基金项目: 国家科技重大专项(No. 2017ZXl0104001–003–001)
详细信息
    作者简介:

    朱曦,女,湖北省荆州市人,硕士在读,主要从事全国诺如病毒暴发和散发监测及毒株变异规律研究,Email:656706711@qq.com

    通讯作者:

    靳淼,Tel:010–58900180, Email: jinmiao37@126.com

  • 中图分类号: R211; R378

Molecular epidemiological characteristics of norovirus outbreaks reported to Chinese norovirus outbreak laboratory surveillance network, 2016–2019

Funds: This study was supported by the National Science and Technology Major Project (No. 2017ZXl0104001–003–001)
More Information
  • 摘要:   目的  了解中国诺如病毒监测网络(CaliciNet China)的发展及2016 — 2019年中国诺如病毒分子流行特征。  方法   收集2016年10月至2019年9月诺如病毒暴发流行病学和病例临床信息及标本,应用荧光反转录聚合酶链式反应(real-time, RT-PCR)进行诺如病毒检测,阳性样本通过RT-PCR扩增、测序,将数据录入CaliciNet China数据库并进行基因分型。  结果  2016年10月至2019年9月,共报告诺如病毒疫情1 153起,对其中776起疫情(67.3%)的阳性样本进行了基因分型。 94.9%的暴发疫情与人–人传播有关,发生在托幼机构或学校(94.4%),每年11月至次年3月为诺如病毒暴发的流行高峰(65.0%)。 57.6%的诺如病毒暴发由GⅡ.2[P16]引起。  结论  GⅡ.2[P16]是 2016年10月至2019年9月引起我国诺如病毒暴发的主要基因型,主要发生在托幼机构或或学校,CaliciNet China正在进行的监测提供了有关毒株基因分型和暴发特征的信息。
  • 图  1  2016年10月至2019年9月诺如病毒暴发数和基因型季节分布

    Figure  1.  Seasonal distribution of norovirus outbreaks and genotypes, October 2016 - September 2019

    表  1  2016年10月至2019年9月CaliciNet China报告的诺如病毒暴发疫情发病数

    Table  1.   Numbers of cases in 861 norovirus outbreaks reported to CaliciNet China, October 2016 - September 2019

     基因型有发病数
    信息的暴发数
    发病数
    范围
    发病数的
    中位数
    GⅡ.1[P33]14343
    GⅡ.1[P16]11212
    GⅡ.2[P2]11515
    GⅡ.2[P16]3733~23617
    GⅡ.3[P12]653~16710
    GⅡ.4 Sydney[P16]25~2415
    GⅡ.4 Sydney[P31]243~5019
    GⅡ.6[P7]354~10212
    GⅡ.8[P8]47~2212
    GⅡ.13[P21]11414
    GⅡ.14[P7]0
    GⅡ.15[P15]28~1713
    GⅡ.17[P17]423~36020
    GⅡ.17[P31]266
    GⅠ.1[P1]199
    GⅠ.2[P2]115~12231
    GⅠ.3[P13]95~727
    GI.5[P4]127~7014
    GⅠ.5[P12]155
    GⅠ.6[P6]177
    GⅠ.6[P11]115~11725
    混合基因型235~34860
    GⅡ 未分型125~11515
    未分型2273~12813
     合计8613~36014
      注:−. 该基因型无发病数信息
    下载: 导出CSV

    表  2  2016年10月至2019年9月CaliciNet China报告的诺如病毒暴发基因型分布

    Table  2.   Genotype distribution of norovirus causing outbreaks reported to CaliciNet China, October 2016 - September 2019

     基因型总计暴发数(起)
    幼儿园小学中学大学其他学校聚会医疗机构集体单位社区及家庭福利院/养老院酒店餐饮机构未知
    GⅡ.1[P33]10100000000000
    GⅡ.1[P1]10000000000001
    GⅡ.1[P16]11000000000000
    GⅡ.2[P2]21010000000000
    GⅡ.2[P16]51923018463131412131124
    GⅡ.3[P12]85551540301020023
    GⅡ.4 Sydney[P16]43000000000001
    GⅡ.4 Sydney[P31]4529411002111005
    GⅡ.6[P7]53241830000310004
    GⅡ.8[P8]52100000010100
    GⅡ.13[P21]71220000000002
    GⅡ.14[P7]10100000000000
    GⅡ.15[P15]42100000000001
    GⅡ.17[P17]5581185507510005
    GⅡ.17[P31]21000000000100
    GⅠ.1[P1]30200000000001
    GⅠ.2[P2]111351100000000
    GⅠ.3[P13]132411200100002
    GⅠ.5[P4]163711101100001
    GⅠ.5[P12]22000000000000
    GⅠ.6[P6]11000000000000
    GⅠ.6[P11]162531200000003
    混合基因型2973104300200000
    GⅡ 未分型1611310100000000
    未分型261106754371305241320
     合计1 1534923401463445118161336633
    下载: 导出CSV

    表  3  2016年10月至2019年9月CaliciNet China报告的诺如病毒暴发疫情传播途径

    Table  3.   Transmission routes of norovirus outbreaks reported to CaliciNet China, October 2016 - September 2019

     场所人传人(起)食源性(起)水源性(起)未知(起)总计(起)
    托儿所4175169492
    小学27710152340
    中学1069724146
    大学2431634
    其他学校4031145
    聚会00011
    医疗机构1800018
    集体单位1320116
    社区及家庭822113
    福利院/养老院30003
    酒店41016
    餐饮机构40026
    未知2103033
     合计91636131881 153
    下载: 导出CSV

    表  4  2016年10月至2019年9月CaliciNet China报告的按传播途径分类的诺如病毒暴发基因型分布

    Table  4.   Genotype distribution of norovirus causing outbreaks reported to CaliciNet China, October 2016–September 2019

     基因型人传人(起)食源性(起)水源性(起)未知(起)总计(起)
    GⅡ.1[P33]10001
    GⅡ.1[P1]00011
    GⅡ.1[P16]10001
    GⅡ.2[P2]10012
    GⅡ.2[P16]41416188519
    GⅡ.3[P12]70411085
    GⅡ.4 Sydney[P16]20024
    GⅡ.4 Sydney[P31]3600945
    GⅡ.6[P7]4220953
    GⅡ.8[P8]41005
    GⅡ.13[P21]40127
    GⅡ.14[P7]00011
    GⅡ.15[P15]20024
    GⅡ.17[P17]40111355
    GⅡ.17[P31]20002
    GⅠ.1[P1]20013
    GⅠ.2[P2]1000111
    GⅠ.3[P13]902213
    GⅠ.5[P4]1310216
    GⅠ.5[P12]20002
    GⅠ.6[P6]10001
    GⅠ.6[P11]1300316
    混合基因型1626529
    GⅡ 未分型1600016
    未分型2159136261
     合计91636131881 153
    下载: 导出CSV
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  • 收稿日期:  2021-06-24
  • 网络出版日期:  2021-08-18
  • 刊出日期:  2021-08-31

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