李嘉铃, 韦俞伽, 董柏青, 陈敏玫, 陈敏, 李海, 苏永健, 李荣秀. 2008-2017年我国手足口病发病和死亡变化趋势研究[J]. 疾病监测, 2022, 37(2): 233-240. DOI: 10.3784/jbjc.202107090395
引用本文: 李嘉铃, 韦俞伽, 董柏青, 陈敏玫, 陈敏, 李海, 苏永健, 李荣秀. 2008-2017年我国手足口病发病和死亡变化趋势研究[J]. 疾病监测, 2022, 37(2): 233-240. DOI: 10.3784/jbjc.202107090395
Li Jialing, Wei Yujia, Dong Baiqing, Chen Minmei, Chen Min, Li Hai, Su Yongjian, Li Rongxiu. Trends of morbidity and mortality of hand foot and mouth disease in China, 2008–2017[J]. Disease Surveillance, 2022, 37(2): 233-240. DOI: 10.3784/jbjc.202107090395
Citation: Li Jialing, Wei Yujia, Dong Baiqing, Chen Minmei, Chen Min, Li Hai, Su Yongjian, Li Rongxiu. Trends of morbidity and mortality of hand foot and mouth disease in China, 2008–2017[J]. Disease Surveillance, 2022, 37(2): 233-240. DOI: 10.3784/jbjc.202107090395

2008-2017年我国手足口病发病和死亡变化趋势研究

Trends of morbidity and mortality of hand foot and mouth disease in China, 2008–2017

  • 摘要:
      目的   分析2008 — 2017年我国手足口病(HFMD)发病和死亡的变化趋势,为制定HFMD疫情防控策略提供科学依据。
      方法   数据来源于中国公共卫生科学数据中心的HFMD发病和死亡数据及国家统计局的人口学资料。 采用Excel 2016 软件建立HFMD报告发病和死亡数据库。 利用Joinpoint 4.9.0.0软件进行Joinpoint回归模型分析,估计2008 — 2017年我国不同年龄组、不同省份年报告HFMD发病率和年报告死亡率的平均年度变化百分比(AAPC),分析HFMD变化趋势。
      结果   从2008年1月至2017年12月共报告HFMD 18183889例(年平均报告发病率为134.75/10万)。 共报告死亡3632例,年平均报告死亡率为 0.027/10万。 2008 — 2017年发病率和死亡率变化趋势较为平稳(P>0.05),但2010 — 2017年死亡率呈下降趋势(APC: –22.98%,95%CI:−29.64%~−15.70%,P<0.05)。 10个省(市)发病率呈上升趋势(P<0.05),4个省(市)发病率呈下降趋势(P<0.05),18个省(市)发病率呈稳定趋势。 5个省份死亡率呈下降趋势(P<0.05)。 HFMD在0~7岁组儿童高发,发病率最高的为1~岁组(3184.19/10万)。 HFMD年平均发病率随年龄增长而逐年降低(t=−2.97,P<0.05)。 <20岁组人群中,HFMD病死率随年龄增长而逐年降低(t=−3.18,P<0.05)。 14个年龄组的年发病率呈上升趋势(P<0.05),12个年龄组的HFMD年发病率呈稳定趋势(P>0.05)。 0~7岁年龄组死亡率的变化趋势平稳(P>0.05)。
      结论   2008 — 2017年我国HFMD发病率和死亡率变化趋势总体较为平稳,但2010 — 2017年死亡率呈下降趋势。 华南、西南、华中、华东地区省份的发病率呈上升趋势;华北、东北地区省份的发病率呈下降趋势。 HFMD在0~7岁组儿童高发。 建议针对不同地区HFMD的疫情变化情况加强HFMD防控工作,以减少HFMD发病和死亡病例。

     

    Abstract:
      Objective   To analyze the trends of morbidity and mortality of hand foot and mouth disease (HFMD) in China from 2008 to 2017, and provide scientific evidence for the development of HFMD prevention and control strategies.
      Methods   The morbidity and mortality data of HFMD in China during this period were collected from China Public Health Science Data Center and the demographic data were collected from National Bureau of Statistics. Software Excel 2016 was used to establish the morbidity and mortality database of HFMD reports. Software JoinPoint 4.9.0.0 was used for JoinPoint regression analysis to estimate the annual average percentage change (AAPC) of reported morbidity and mortality of HFMD in different age groups and in different provinces in China from 2008 to 2017, and analyze the changing trend of HFMD morbidity and mortality.
      Results   A total of 18 183 889 cases of HFMD were reported from January 2008 to December 2017, the average annual reported morbidity was 134.75/100 000. A total of 3 632 deaths were reported, with an annual average reported mortality of 0.027/100 000. The morbidity and mortality were stable from 2008 to 2017 (P>0.05), but the mortality showed a decreasing trend from 2010 to 2017 (APC: −22.98%, 95%CI: −29.64% to −15.70%, P<0.05). The morbidity in 10 provinces (municipalities) showed an increasing trend (P<0.05), the morbidity in 4 provinces (municipalities) showed decreasing trend (P<0.05), the morbidity in 18 provinces (municipalities) remained stable, and the mortality showed decreasing trend in 5 provinces (P<0.05). The incidence of HFMD was high in children aged 0–7 years, and the highest morbidity was in children aged 1 year (3 184.19/100 000). The average annual morbidity of HFMD decreased with age (t=−2.97, P<0.05). The case fatality rate of HFMD in age group <20 years decreased with age (t=−3.18, P<0.05). The annual morbidity of HFMD in 14 age groups showed an increasing trend (P<0.05), and the annual morbidity of HFMD in 12 age groups remained stable (P>0.05). The mortality in age group 0–7 years remained stable (P>0.05).
      Conclusion   The overall HFMD morbidity and mortality in China from 2008 to 2017 were relatively stable, but the mortality showed a decreasing trend from 2010 to 2017. The morbidity of HFMD showed increasing trend in Southern China, Southwestern China, Central China and Eastern China, but the morbidity of HFMD declined in northern China and northeastern China. The morbidity of HFMD was higher in children aged 0 to 7 years. It is suggested that HFMD prevention and control should be strengthened according to the change of HFMD epidemic in different areas to reduce the morbidity and mortality of HFMD.

     

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