2011－2019年我国G9P[8]型A组轮状病毒腹泻住院患儿流行病学和临床特征分析

魏宇航; 李静欣; 彭蕊; 王萌璇; 孙晓曼; 章青; 王宏; 范佳欣; 李丹地; 段招军

doi:10.3784/jbjc.202111110589

2011－2019年我国G9P[8]型A组轮状病毒腹泻住院患儿流行病学和临床特征分析

doi: 10.3784/jbjc.202111110589

魏宇航^{1, 2,},
李静欣¹,
彭蕊¹,
王萌璇¹,
孙晓曼¹,
章青¹,
王宏¹,
范佳欣¹,
李丹地^1, ,,
段招军¹

1.
中国疾病预防控制中心病毒病预防控制所, 国家卫生健康委员会医学病毒和病毒病重点实验室, 北京 102206
2.
甘肃中医药大学公共卫生学院, 甘肃兰州 730000

基金项目: 国家自然科学基金（No. 21934005）

详细信息

作者简介:
魏宇航，男，河北省安国市人，在读硕士，就读于甘肃中医药大学公共卫生学院，主要从事轮状病毒相关研究，Email：yuhang960811@163.com

通讯作者:
李丹地， Tel：010–58900899，Email：dandili@126.com

中图分类号: R211; R373.2
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- 被引次数: 0
出版历程
- 收稿日期: 2021-11-11
- 网络出版日期: 2022-03-08
- 刊出日期: 2022-07-14

Epidemiological and clinical characteristics of hospitalized children with G9P[8] group A rotavirus diarrhea in China from 2011 to 2019

1.
NHC Key Laboratory of Medical Viruses and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
2.
College of Public Health Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, China

Funds: This study was supported by the National Natural Science Foundation of China (No. 21934005)

More Information

Corresponding author: Li Dandi , Email: dandili@126.com

摘要

摘要: 目的了解我国G9P[8]型A组轮状病毒（Group A Rotavirus, RVA）腹泻住院患儿的流行病学和临床特征。方法收集2011年1月至2019年12月我国病毒性腹泻监测网络数据。监测网数据采用EpiData 3.0软件采集，采用Excel 2010软件数据整理，应用SPSS 26.0软件数据分析。结果 2011年1月至2019年12月采集到我国病毒性腹泻监测网络5岁以下急性胃肠炎住院患儿标本共计47 386份，其中G9P[8]型RVA阳性率为54.50％（8 149/14 952），G9P[8]型RVA在男性患儿中占比低于女性患儿。 G9P[8]型RVA的流行季节为秋冬季。 G9P[8]型RVA相对于非G9P[8]型RVA患儿在发热（59.79％，4 872/8 149）、呕吐（53.87％，4 390/8 149）、腹泻（92.93％，7 573/8 149）、肠道外症状的呼吸道症状（29.30％，2 388/8 149）、神经系统症状（2.07％，169/8 149）、mber>/8 149）、神经系统症状（2.07％，169/8 149）、皮疹、肺炎、败血症（8.21％，669/8 149）等症状/体征多发且严重。结论 2011年1月至2019年12月我国G9P[8]型RVA逐渐成为我国的流行优势毒株，季节高峰为秋冬季，G9P[8]型RVA症状更重。本研究为RVA防控提供基础数据支持，为RVA疫苗候选毒株选择提供参考。
- 轮状病毒 /
- 流行特征 /
- 腹泻 /
- G9P[8]型A组轮状病毒 /
- 临床症状
Abstract: Objective To understand the epidemiological and clinical characteristics of G9P[8] group A rotavirus (RVA) in hospitalized children with diarrhea in China. Methods The data of viral diarrhea surveillance network in China from January 2011 to December 2019 were collected, EpiData 3.0 software were used for data collection of viral diarrhea monitoring network, Excel 2010 software were used for data collation, and SPSS 26.0 software was used for data analysis. Results From January 2011 to December 2019, a total of 47 386 specimens of hospitalized children with acute gastroenteritis under 5 years old were collected by the viral diarrhea surveillance network in China. The positive rate of G9P[8] RVA was 54.50％ (8 149/14 952).The positive rate of G9P[8] RVA in male children was lower than in female children. The epidemic season is autumn and winter. Compared with non-G9P[8] RVA children, G9P[8] RVA children had more severe and higher proportion of fever (59.79％, 4 872/8 149), vomiting (53.87％, 4 390/8 149), diarrhea (92.93％, 7 573/8 149), respiratory symptoms (29.30％, 2 388/8 149), neurological symptoms (2.07％, 169/8 149), rash, pneumonia and sepsis (8.21％, 669/8 149) . Conclusion From January 2011 to December 2019, G9P[8] RVA gradually became the main predominant in China. The autumn and winter were G9P[8] RVA seasonal peaks, and the symptoms of G9P[8] RVA were more severe. This study provides data support for the prevention and control of G9P[8] RVA, and reference for the selection of rotavirus vaccine strain.
- Rotavirus /
- Epidemic characteristics /
- Diarrhea /
- G9P[8] RVA /
- Clinical symptoms

HTML全文

图 1 2011－2019年我国病毒性腹泻监测网络G9P[8]型RVA阳性检出情况

Figure 1. Detection of group A rotavirus G9P[8] in viral diarrhea surveillance network in China, 2011–2019

下载: 全尺寸图片幻灯片

图 2 2011－2019年我国病毒性腹泻监测网络G9P[8]型RVA月分布

Figure 2. Monthly distribution of detection of group A rotavirus G9P[8] in viral diarrhea surveillance network in China, 2011–2019

下载: 全尺寸图片幻灯片

图 3 2011－2019我国病毒性腹泻G9P[8]型RVA时间变化趋势

Figure 3. Time trend of detection of group A rotavirus G9P[8] in viral diarrhea cases in China, 2011–2019

下载: 全尺寸图片幻灯片

表 1 G9P[8]型RVA和非G9P[8]型RVA临床表现分布

Table 1. Clinical manifestations of group A rotavirus G9P[8] and non-group A rotavirus G9P[8]-caused diarrhea cases

临床表现	G9P[8]型		非G9P[8]型
临床表现	病例数	构成比（%）	病例数	构成比（%）
发热	4 872	59.79	3 901	57.34
呕吐	4 390	53.87	3 383	49.73
腹泻	7 573	92.93	6 219	91.42
呼吸道症状	2 388	29.30	1 701	25.00
神经系统症状	169	2.07	84	1.23
皮疹、肺炎、败血症等并发症	669	8.21	269	3.95

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