Objective   To analyze the changes in incidence of notifiable infectious diseases in Jiading district of Shanghai in the context of COVID-19 epidemic.

  Methods   The incidence data of notifiable infectious disease in Jiading during 2017−2021 were collected for the comparison of the incidence rates before and after the implementation of COVID-19 prevention and control measures.

  Results   The incidence rate of notifiable infectious diseases in Jiading was 167.59/100000in 2020, 60.20% lower than the average level during 2017-2019 (421.04/100000) (χ²=2424.369, P＜0.001）and the incidence rate was 213.82/100000 in 2021, 49.22% lower than the average level during 2017 − 2019 (χ²=1 578. 996, P<0.001). The incidence of class B and C infectious diseases in 2020 and 2021 were lower than the average incidence during 2017−2019, and the incidence of class B infectious diseases decreased by 38.79% in 2020 and 30.70% in 2021, respectively. The incidence rate of class C decreased by 71.23% in 2020 and 58.76%in 2021, respectively. The incidence rates of intestinal infectious disease, respiratory infectious disease, blood infectious disease and sexually transmitted disease during 2020 − 2021 were lower than the average levels during 2017−2019, which decreased by 59.27%, 68.02% and 36.52% respectively in 2020, and decreased by 37.96%, 56.37% and 30.51% respectively in 2021.The incidence rates of HFMD in 2020 and 2021 were still highest during 2020 − 2021 ( 39.01/100000 and 75.87/100000).

  Conclusion   The implementation of COVID-19 prevention and control measures had influence on the incidence of notifiable infectious diseases with different transmission routes, especially the respiratory infectious diseases, but the influence on the rank of top five notifiable infectious diseases was not obvious.