2011-2021年湖北省荆州市手足口病流行特征及病原学监测分析

刘天 肖新宇 吴杨 陈琦 阮德欣 姚梦雷 侯清波 黄继贵 陈红缨

刘天, 肖新宇, 吴杨, 陈琦, 阮德欣, 姚梦雷, 侯清波, 黄继贵, 陈红缨. 2011-2021年湖北省荆州市手足口病流行特征及病原学监测分析[J]. 疾病监测, 2023, 38(4): 408-414. doi: 10.3784/jbjc.202206220284
引用本文: 刘天, 肖新宇, 吴杨, 陈琦, 阮德欣, 姚梦雷, 侯清波, 黄继贵, 陈红缨. 2011-2021年湖北省荆州市手足口病流行特征及病原学监测分析[J]. 疾病监测, 2023, 38(4): 408-414. doi: 10.3784/jbjc.202206220284
Liu Tian, Xiao Xinyu, Wu Yang, Chen Qi, Ruan Dexin, Yao Menglei, Hou Qingbo, Huang Jigui, Chen Hongying. Epidemiological and etiological characteristics of hand foot and mouth disease in Jingzhou, Hubei, 2011−2021[J]. Disease Surveillance, 2023, 38(4): 408-414. doi: 10.3784/jbjc.202206220284
Citation: Liu Tian, Xiao Xinyu, Wu Yang, Chen Qi, Ruan Dexin, Yao Menglei, Hou Qingbo, Huang Jigui, Chen Hongying. Epidemiological and etiological characteristics of hand foot and mouth disease in Jingzhou, Hubei, 2011−2021[J]. Disease Surveillance, 2023, 38(4): 408-414. doi: 10.3784/jbjc.202206220284

2011-2021年湖北省荆州市手足口病流行特征及病原学监测分析

doi: 10.3784/jbjc.202206220284
详细信息
    作者简介:

    刘天,男,湖北省荆州市人,主管医师,主要从事急性传染病防制工作,Email:jzcdclt@163.com

    肖新宇,女,湖北省荆州市人,助理医师,主要从事急性传染病防制工作,Email:981699403@qq.com

    通讯作者:

    陈红缨,Tel:0716–8100252 ,Email:348166087@qq.com

  • 中图分类号: R211; R373

Epidemiological and etiological characteristics of hand foot and mouth disease in Jingzhou, Hubei, 2011−2021

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  • 摘要:   目的  描述2011—2021年湖北省荆州市手足口病(HFMD)流行病学特征,分析重症病例危险因素,为该地区HFMD防制提供科学依据。  方法  自《中国疾病预防控制信息系统》收集荆州市HFMD病例、病原学监测结果、聚集性和暴发疫情资料。采用描述性流行病学方法描述HFMD三间分布特征,计算发病率、重症率、占比、标本检测阳性率及亚型占比。 采用logistic回归分析HFMD重症的危险因素。  结果  2011—2021年荆州市累计报告HFMD 62 521例,年均发病率100.87/10万,重症数146例,重症率0.23%,死亡5例,病死率0.80/万,重症死亡率3.42%。 发病率随年份无明显趋势变化($ {{{r}}_{\rm{s}}} $=−0.21,P=0.539);重症率随年份呈下降趋势($ {{{r}}_{\rm{s}}} $=−0.66,P= 0.031)。 HFMD发病呈双峰型特点(4—6月和11—12月);县(市/区)发病率介于51.85/10万~140.23/10万,高发地区随年份不断变化;人群分类以散居儿童(69.58%)和幼托儿童(28.18%)为主,男性(59.01/10万)发病率高于女性(41.66/10万,RR=1.42,95%CI:1.39~1.44);以5岁以下儿童(96.08%)为主。 男性相较女性、低年龄儿童、中心城区相较江南片区、流行季节、发病至就诊时间长更易进展为重症病例(均比值比>1,均P<0.05)。肠道病毒71型( EV71)为重症病例(53.57%)和死亡病例(80.00%)主要病原。 报告聚集性疫情89起和暴发疫情5起,发生场所以幼托机构(87起,92.55%)为主。 病原学监测阳性率为70.88%(3 488/4 921);其中EV71、柯萨奇病毒A组16型、其他型分别占16.66%、27.24%、56.10%,其他型占比随年份增加呈上升趋势($ {{{r}}_{\rm{s}}} $=0.75,P=0.007)。  结论  荆州市HFMD维持较高发病水平,近年来重症率明显下降。 荆州市HFMD有明显时空异质性。其他型肠道病毒已成为荆州市HFMD主要病原。
  • 图  1  2011-2021年荆州市手足口病发病率、重症率季节指数分布

    Figure  1.  Seasonal index of incidence rate and severe rate of HFMD in Jingzhou, 2011−2021

    图  2  2011-2021年荆州市0~9岁儿童手足口病发病率分布

    Figure  2.  Incidence of HFMD in children aged 0−9 years in Jingzhou, 2011−2021

    图  3  2011-2021年荆州市手足口病重症病例危险因素分析

    注:蓝点表示OR值点估计值,黄色线段表示OR值的95%置信区间,红色参考线对应OR值为1的位置

    Figure  3.  Risk factors for severe cases of HFMD in Jingzhou, 2011−2021

    图  4  2011-2021年荆州市手足口病病原学监测

    Figure  4.  Etiological surveillance of HFMD in Jingzhou, 2011−2021

    表  1  2011-2021年荆州市手足口病疫情概况

    Table  1.   Epidemic situation of HFMD in Jingzhou, 2011−2021

    年份病例数
    (例)
    重症数
    (例)
    死亡数
    (例)
    发病率
    (/10万)
    重症率
    (%)
    病死率
    (/万)
    20113 5635162.600.142.81
    20129 022193158.170.213.33
    20133 71011065.020.300.00
    20147 027411123.010.581.42
    20155 895160102.900.270.00
    20168 581320150.390.370.00
    20175 25810092.280.190.00
    20186 78040120.180.060.00
    20197 45060133.270.080.00
    20201 8861033.860.050.00
    20213 3491064.020.030.00
    合计62 5211465100.870.230.80
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  • 收稿日期:  2022-06-22
  • 网络出版日期:  2023-03-17
  • 刊出日期:  2023-04-30

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