2011-2020年广东省HIV感染孕产妇不良妊娠结局情况及其影响因素分析

蔡敏 高峰 刘悦 张书豪 高爽

蔡敏, 高峰, 刘悦, 等. 2011-2020年广东省HIV感染孕产妇不良妊娠结局情况及其影响因素分析[J]. 疾病监测, 2022, 37(12): 1558-1562. doi: 10.3784/jbjc.202206270300
引用本文: 蔡敏, 高峰, 刘悦, 等. 2011-2020年广东省HIV感染孕产妇不良妊娠结局情况及其影响因素分析[J]. 疾病监测, 2022, 37(12): 1558-1562. doi: 10.3784/jbjc.202206270300
Cai Min, Gao Feng, Liu Yue, et al. Analysis on adverse pregnancy outcome of HIV-infected pregnant women and influencing factors in Guangdong, 2011−2020[J]. Dis Surveill, 2022, 37(12): 1558-1562. doi: 10.3784/jbjc.202206270300
Citation: Cai Min, Gao Feng, Liu Yue, et al. Analysis on adverse pregnancy outcome of HIV-infected pregnant women and influencing factors in Guangdong, 2011−2020[J]. Dis Surveill, 2022, 37(12): 1558-1562. doi: 10.3784/jbjc.202206270300

2011-2020年广东省HIV感染孕产妇不良妊娠结局情况及其影响因素分析

doi: 10.3784/jbjc.202206270300
详细信息
    作者简介:

    蔡敏,男,安徽省安庆市人,硕士,主要从事预防艾滋病、梅毒和乙肝母婴传播工作,Email:dawn_caimin@163.com

    通讯作者:

    高爽,Tel:020−39151605,Email:gaoshuang020@126.com

  • 中图分类号: R211; R512.91

Analysis on adverse pregnancy outcome of HIV-infected pregnant women and influencing factors in Guangdong, 2011−2020

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  • 摘要:   目的   描述广东省人类免疫缺陷病毒(HIV)感染孕产妇不良妊娠结局的情况,分析导致不良妊娠结局的影响因素,促进艾滋病感染孕产妇及暴露儿童的健康。  方法   对广东省2011—2020年所有区/县确认的3 438例HIV感染孕产妇的相关信息进行χ2检验和非条件logistic回归分析。  结果   共3 438例HIV感染孕妇纳入研究, 955例孕妇发生不良妊娠结局,不良妊娠结局发生率为27.78%。 不同的文化程度、初检时期、传播途径、产次和确认感染时期和妊娠高血压会影响HIV感染孕产妇不良妊娠结局的发生,差异有统计学意义(P<0.05)。 多因素logistic回归分析显示,注射毒品感染、产时或产后确认感染和患有妊娠高血压的HIV感染孕产妇发生不良妊娠结局的OR值分别是1.65(1.04~2.58)、0.61(0.48~0.78)和2.27(1.35~3.80)。  结论   传播途径、确认感染时期及妊娠高血压和HIV感染孕产妇发生不良妊娠结局有关。 需要高度重视HIV感染孕妇的生殖健康,提供优质的咨询服务和孕期保健服务,保障HIV感染孕产妇的健康,改善妊娠结局。
  • 表  1  人类免疫缺陷病毒感染孕产妇妊娠结局影响因素的单因素分析

    Table  1.   Univariate analysis on influencing factors of adverse pregnancy outcome of HIV-infected pregnant women

     因素HIV感染 孕产妇妊娠结局χ2P
    健康分娩 不良妊娠结局
    数量(例)构成比(%)数量(例)构成比(%)数量(例)构成比(%)
    年龄组(岁) 4.88 0.087
     ≤20 183 5.32 135 73.77 48 26.23
     21~ 1 867 54.30 1374 73.59 493 26.41
     31~ 1 388 40.38 974 70.17 414 29.83
    文化程度 9.93 0.019
     初中及以下 2 412 70.16 1 756 72.80 656 27.20
     高中 610 17.74 436 71.48 174 28.52
     大学及以上 238 6.92 180 75.63 58 24.37
     不详 177 5.15 111 62.71 66 37.29
    民族 0.16 0.689
     汉族 2 901 84.38 2 091 72.08 810 27.92
     其他 534 15.79 390 73.03 144 26.97
    职业 3.08 0.079
     家务及待业 1 796 52.24 1 321 73.55 475 26.45
     其他 1 641 47.73 1 163 70.83 479 29.17
    婚姻状况 3.51 0.061
     已婚(初婚或再婚) 2 746 79.87 2 004 72.98 742 7.02
     单身 692 20.13 479 69.32 212 30.68
    初检时期 9.02 0.029
     孕早期 1 200 34.90 844 70.33 356 29.67
     孕中期 995 28.94 710 71.36 285 28.64
     孕晚期 953 27.72 723 75.87 230 24.13
     不详 290 8.44 206 71.03 84 28.97
    传播途径 7.67 0.022
     性传播 1 793 52.15 1 290 71.95 503 28.05
     注射毒品 87 2.53 52 59.77 35 40.23
     其他或不详 1 557 45.32 1 141 73.28 416 26.72
    产次 6.46 0.011
     初产妇 1 166 33.92 810 69.47 356 31.53
     经产妇 2 272 66.38 1673 73.64 599 26.36
    确认感染时期 8.27 0.016
     孕前 1 762 51.25 1246 70.72 516 29.28
     孕期 1 110 32.29 807 72.71 303 27.29
     产时或产后 566 16.46 430 75.97 136 24.03
    开始用药时期 5.23 0.160
     孕期 2 273 66.11 1 649 72.55 624 27.45
     产时 223 6.49 183 82.06 40 17.94
     产后或未用药 942 27.40 651 69.11 291 30.89
    中重度贫血 0.55 0.457
     是 3 300 95.99 2 379 72.09 921 27.91
     否 138 4.01 104 75.36 34 24.64
    妊娠高血压 8.65 0.003
     是 62 1.80 34 54.84 28 45.16
     否 3 376 98.20 2 449 72.54 927 27.46
    妊娠合并糖尿病 0.00 1.000
     是 3 345 97.29 2 416 72.23 929 27.77
     否 93 2.71 67 72.04 26 27.96
    下载: 导出CSV

    表  2  人类免疫缺陷病毒感染孕产妇不良妊娠结局多因素非条件logistic回归分析

    Table  2.   Multivariate conditional logistic regression analysis on adverse pregnancy outcomes of HIV-infected pregnant women

      因素β$s_{ \bar x}$χ2PExp (β)95%CI
    常数−0.630.1130.39<0.0010.530.43~0.67
    文化程度
     初中及以下1.00
     高中−0.020.100.050.8200.980.80~1.19
     大学及以上−0.280.163.010.0830.750.55~1.03
     不详0.490.178.670.0031.631.17~2.25
    初检时期
     孕早期1.00
     孕中期−0.040.100.180.0700.960.80~1.16
     孕晚期−0.140.111.610.2050.860.70~1.08
     不详0.080.150.270.6051.080.80~1.46
    传播途径
     性传播1.00
     注射毒品0.500.234.710.0301.651.04~2.58
     其他或不详−0.060.080.530.4650.940.81~1.10
    产次
     初产妇1.00
     经产妇−0.130.082.210.1370.880.75~1.04
    确认感染时期
     孕前1.00
     孕期−0.180.103.350.0670.840.70~1.01
     产时或产后−0.490.1215.52<0.0010.610.48~0.78
    妊娠高血压
     否1.00
     是0.820.269.720.0022.271.35~3.80
    下载: 导出CSV
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  • 收稿日期:  2022-06-27
  • 网络出版日期:  2022-11-28
  • 刊出日期:  2022-12-01

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