Objective To analyze the epidemiological characteristics and incidence trend of mumps in Guangzhou of Guangdong province from 2008 to 2022.

Methods The incidence data of mumps and population data in Guangzhou during this period were obtained from the infectious disease surveillance subsystem and basic information system of China Information System for Disease Control and Prevention for a descriptive analysis, and Joinpoint regression model was used to analyze the incidence trend of mumps.

Results A total of 53 993 cases of mumps were reported in Guangzhou from 2008 to 2022, with an annual average incidence of 26.08/100 000. The cases mainly occurred in children and adolescents aged 0−14 years, and the incidence was highest in children aged 0−4 years, followed by children aged 5−9 years. The annual incidence peak occurred during May-July, and there were two incidence peaks in some years, mainly in winter and summer. Joinpoint regression analysis results showed that the incidence rate of mumps in Guangzhou showed an upward trend from 2008 to 2011 (β₁=0.268, P=0.006), with an average annual increase of 30.70%. The incidence rate showed a downward trend from 2011 to 2014 (β₂=−0.421, P=0.018), with an average annual decrease of 34.38%, and continued to decline from 2014 to 2022, with an average annual decrease of 10.96% (β₃=−0.116, P=0.002).

Conclusion Overall, the incidence of mumps in Guangzhou showed a downward trend from 2008 to 2022. In the future, it is necessary to further strengthen the measles-mumps-rubella vaccine immunization. Schools and child care settings are the key places in mumps prevention and control, and comprehensive measures should be taken to control the epidemic of mumps effectively.