Objective To analyze the epidemiological characteristics and spatiotemporal clustering of hand, foot and mouth disease (HFMD) in Jiading district of Shanghai from 2015 to 2022, and provide evidence for the precise prevention and control of HFMD.

Methods The incidence data of HFMD in Jiading from 2015 to 2022 were collected from the infectious disease reporting information management system of Chinese Center for Disease Control and Prevention for a descriptive epidemiological analysis. Software saTScan 10.1 was used to analyze the monthly spatiotemporal clustering of HFMD at township level. Software ArcGIS 10.8 was used to visualize the results.

Results The annual incidence of HFMD in Jiading showed seasonality, with the peak during April-July and the sub-peak during September-November. The case count was higher in men than in women (1.47∶1), and the cases in children under 5 years old accounted for 88.37% of the total. Spatiotemporal scanning analysis indicated that there were 1–3 clustering of HFMD cases every year in Jiading from 2015 to 2022, and the main clustering areas were Nanxiang, Malu, Jiangqiao.

Conclusion The overall incidence rate of HFMD in Jiading showed a decreasing trend, and had spatiotemporal clustering. It is necessary to strengthen prevention and control of HFMD in key areas and periods with high incidence of HFMD.