Objective To understand the epidemiological characteristics and long-term incidence trend of mumps in Guilin, Guangxi Zhuang autonomous region, from 2012 to 2023, and provide evidence for the prevention and control of mumps.

Methods The incidence data of mumps in Guilin from 2012 to 2023 were collected from China Disease Control and Prevention Information System for a descriptive epidemiological analysis. Joinpoint regression model was used to analyze the incidence trend of mumps in Guilin from 2012 to 2023.

Results From 2012 to 2023, a total of 13622 mumps cases were reported in Guilin, without fatal cases, and the average annual incidence rate was 22.86/100 000. The cases mainly occurred in children and adolescents aged 2−14 years, with the highest incidence rate in age group 5− years, followed by age group 4− years. The annual incidence peaks occurred during May-July and November-December. The cases were mainly distributed in Xiufeng, Xiangshan, Lingchuan, Quanzhou and Lipu, where a total of 6 954 cases were reported. The Joinpoint regression analysis revealed a slow declining trend in the overall incidence rate reported in population in Guilin from 2012 to 2023 (AAPC=−5.67%, P=0.010).

Conclusion The overall incidence rate of mumps reported in Guilin from 2012 to 2023 showed a decreasing trend, but it was still at a high level, and in the future, it is necessary to continue to implement the routine MuCV vaccination strategy, and carry out active and comprehensive preventive and control to effectively control the incidence of mumps.