2017-2022年天津市滨海新区出生队列儿童肺炎球菌疫苗接种情况分析

Analysis on pneumonia vaccine immunization in birth cohort of children in Binhai new district of Tianjin, 2017−2022

  • 摘要:
    目的 分析2017—2022年天津市滨海新区出生队列儿童肺炎球菌疫苗接种情况,了解儿童肺炎球菌疫苗免疫覆盖水平及首剂13价肺炎球菌多糖结合疫苗(PCV13)接种情况。
    方法 收集2017—2022年天津市免疫规划信息系统中出生队列儿童的肺炎球菌疫苗接种信息,计算肺炎球菌疫苗接种率及PCV13首剂接种月龄构成比,利用Mann-Kendall趋势检验分析不同出生年份儿童肺炎球菌疫苗接种率及PCV13首剂接种月龄构成比的变化趋势,利用χ2检验分析不同户籍儿童的接种率差异情况。
    结果 2017—2022年天津市滨海新区出生队列儿童131 802人,PCV13≥1剂次接种率、≥3剂次接种率、基础免疫接种率分别为23.47%、18.51%、20.56%;2017—2021年出生队列儿童117 567人,23价肺炎球菌多糖疫苗(PPV23)接种率为13.96%。 经Mann-Kendall趋势检验,2017—2022年不同出生年份本地儿童及流动儿童PCV13≥1剂次(均Z=2.630,P<0.05)、PCV13≥3剂次(均Z=2.630,P<0.05)、PCV13基础免疫接种率(均Z=2.254,P<0.05)均呈逐年增加趋势;2017—2021年不同出生年份的本地儿童及流动儿童PPV23≥1剂次接种率呈逐年下降趋势(均Z=–2.205,P<0.05)。 各年份出生本地儿童的PCV13≥1剂次、PCV13≥3剂次、PCV13基础免疫接种率高于流动儿童(P<0.05);2017、2018年出生儿童中,本地儿童PPV23≥1剂次接种率高于流动儿童,差异具有统计学意义(P<0.05)。 2017—2022年出生队列儿童PCV13首剂接种月龄中位数为2(2,4)月龄;不同出生年份本地儿童及流动儿童PCV13首针接种≤2月龄的人数构成比呈逐年增加趋势(均Z=2.254,P<0.05),PCV13首针接种≥16月龄的人数构成比呈逐年下降趋势(均Z=−2.630,P<0.05)。
    结论 2017—2022年天津市滨海新区的肺炎球菌疫苗免疫覆盖水平随年份增长呈增加趋势,但流动儿童低于本地儿童。 PCV13疫苗的首剂接种月龄中位数随年份增长逐年提前,但流动儿童要晚于本地儿童。 提示要关注流动儿童肺炎球菌疫苗接种情况,可针对2月龄内流动儿童家长开展PCV13相关知识宣传。

     

    Abstract:
    Objective To understand the coverage level of pneumonia vaccine and the first dose of the 13-valent pneumococcal polysaccharide conjugate vaccine (PCV13) immunizations in children born in Binhai new district of Tianjin from 2017 to 2022.
    Methods The data about pneumonia vaccine immunization in children born in Binhai during 2017−2022 were collected from Tianjin Immunization Information System, the pneumonia vaccine immunization coverage rate was calculated and the age distribution of first dose of PCV13 vaccine immunization was analyzed, Mann-Kendall trend test was used to analyze the trend of pneumonia vaccine immunization coverage rate and the age distribution of the first dose of PCV13 vaccination in different years, and χ2 test was used to analyze the differences between local children and migrant children.
    Results A total of 131802 children were enrolled in the birth cohort from 2017 to 2022. The ≥1 dose, ≥3 dose and primary immunization coverage rates of PCV13 in 2017−2022 birth cohort were 23.47%, 18.51% and 20.56%, respectively. A total of 117567 children were enrolled in the birth cohort from 2017 to 2021. The coverage rate of one dose 23-valent pneumococcal polysaccharide vaccine (PPV23) in 2017−2021 birth cohort was 13.96%. Mann-Kendall trend test showed that the coverage rates of ≥1 dose (Z= 2.630, P<0.05), ≥3 doses (Z= 2.630, P<0.05) and primary immunizations of PCV13 (Z= 2.254, P<0.05) increased with year in both local children and migrant children in 2017-2022 birth cohort. The overage rate of one dose PPV23 decreased with year in both local children and migrant children in 2017-2021 birth cohort (Z=-2.205, P<0.05). In 2017−2022 birth cohort, the result of χ2 test showed that the coverage rates of ≥1 dose PCV13, ≥3 doses PCV13 and primary immunizations of PCV13 were higher in local children than in migrant children (P<0.05) and in children born in 2017 and 2018, the coverage rate of ≥1 dose PPV23 was higher in local children than in migrant children, the difference was significant (P<0.05). The median age for the first dose of PCV13 was 2 (2, 4) months. According to Mann-Kendall trend test, the proportion of children who received the first dose of PCV13 before age 3 months showed an increasing trend year by year (Z= 2.254, P<0.05). The proportion of children who received the first dose of PCV13 at or after age 16 months showed a decreasing trend year by year (Z= −2.630, P<0.05) in local children or migrant children.
    Conclusion The coverage level of pneumonia vaccine immunization in Binhai new district of Tianjin increased from 2017 to 2022, but the coverage level was lower in migrant children than in local children. From 2017 to 2022, the median age for the first dose of PCV13 vaccine immunization increased year by year, but the median age was higher in migrant children than in local children. It is suggested to pay attention to the coverage level of pneumonia vaccine immunization in migrant children, and conduct health education about PCV13 in parents of migrant children under 2 months of age.

     

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