1990－2019年海南省感染性心内膜炎疾病负担及变化趋势分析

陈赛苦; 朱瑞轩; 乔利春; 郭顺杰; 文欣悦; 王兴任; 江娟; 周脉耕; 刘莹; 何滨; 韩晶

doi:10.3784/jbjc.202407040392

1990－2019年海南省感染性心内膜炎疾病负担及变化趋势分析

Disease burden by infective endocarditis and trend in Hainan, 1990−2019

摘要

摘要:
目的分析1990—2019年海南省感染性心内膜炎（IE）疾病负担和变化趋势，为全省IE疾病防控工作提供基础依据。
方法使用2019年全球疾病负担研究数据库中发病率、死亡率、伤残损失寿命年（YLD）、早死损失寿命年（YLL）和伤残调整寿命年（DALY）及其年龄标准化率等指标对1990—2019年海南省不同性别、年龄人群的IE疾病负担变化进行分析。计算年度变化百分比和平均年度变化百分比分析IE疾病负担变化趋势，并与全国IE情况进行比较。
结果 1990—2019年，海南省IE的年龄标化发病率（ASIR）和年龄标化YLD率（ASYLDR）呈上升趋势，年龄标化死亡率（ASMR）、年龄标化YLL率（ASYLLR）和年龄标化DALY率（ASDR）呈下降趋势。2019年，海南省IE的ASIR为15.14/10万，ASMR为0.27/10万。 DALY、YLD、YLL分别为762.70人年、22.55人年和740.15人年，其年龄标化率分别为7.63/10万、0.23/10万、7.40/10万，其中YLL占DALY的97.04%。 2019年海南省IE的ASDR、ASIR和ASMR均表现为男性高于女性。在不同年龄组中，≥95岁人群的发病率、死亡率和DALY率最高。 1990—2019年，海南省IE的ASIR高于全国平均水平，其余疾病负担指标提示两者之间的差距正在不断缩小。
结论 1990—2019年海南省IE疾病负担整体呈下降趋势，其中ASIR和ASYLDR呈上升趋势。未来海南省ASIR可能继续呈上升趋势，应当加强对老年群体的关注和降低伤残所致的疾病负担。

Abstract:
Objective To analyze the disease burden caused by infective endocarditis in Hainan province from 1990 to 2019 and provide evidence for the prevention and control of infective endocarditis in Hainan.
Methods The data of Global Burden of Disease 2019 (GBD 2019), including the incidence rate, mortality rate, years lived with disability (YLD), years of life lost (YLL), disability-adjusted of life years (DALY) of infective endocarditis and their age-standardized rates, were used to analyze the changes in the disease burden of infective endocarditis by gender and age in Hainan from 1990 to 2019. Annual percentage change (APC) and average annual percentage change (AAPC) were calculated to analyze the trend of the disease burden by infective endocarditis and compare with the national level.
Results From 1990 to 2019, the age-standardized incidence rate (ASIR) and age-standardized YLD rate (ASYLDR) of infective endocarditis showed upward trends, while the age-standardized mortality rate (ASMR), age-standardized YLL rate (ASYLLR) and age-standardized DALY rate (ASDR) showed downward trends in Hainan. In 2019, the ASIR and ASMR of infective endocarditis were 15.14/100 000 and 0.27/100 000, respectively. The DALY, YLD and YLL were 762.70, 22.55 and 740.15 person years, respectively, and the age standardized rates were 7.63/100 000, 0.23/100 000 and 7.40/100 000, respectively. The YLL accounted for 97.04% of DALY. In 2019, the ASDR, ASIR and ASMR of infective endocarditis were higher in men than in women. In different age groups, the incidence rate, mortality rate and DALY rate were highest in age group ≥95 years. From 1990 to 2019, the ASIR of infective endocarditis was higher in Hainan compared with the national average level, but the differences in other indicators became smaller.
Conclusion From 1990 to 2019, the overall disease burden by infective endocarditis showed a mitigation trend in Hainan, but the ASIR and ASYLDR showed upward trends. The ASIR might continue to increase in the future. More attention should be paid to the elderly to reduce the disease burden of disease caused by disability.

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