2018－2020年天津市某医院176例体检者血清游离脂肪酸与中青年高尿酸血症的相关性研究

李慧丹; 魏星; 杨松涛; 赵伟; 黄力平

doi:10.3784/jbjc.202407150414

2018－2020年天津市某医院176例体检者血清游离脂肪酸与中青年高尿酸血症的相关性研究

Correlation between serum free fatty acids and hyperuricemia, a study in 176 young and middle-aged adults receiving health examination in a hospital in Tianjin, 2018–2020

摘要

摘要:
目的探讨人体血清游离脂肪酸（FFA）水平与中青年高尿酸血症（HUA）的相关性。
方法随机选取2018年3月至2020年3月在天津医科大学朱宪彝纪念医院体检的表观健康中青年男性176例，依据HUA诊断标准分为HUA组（n=117）和健康对照组（n=59）。采集年龄、体质量指数（BMI）等一般资料，以及FFA、血尿酸（SUA）、总胆固醇（TC）、三酰甘油（triglyceride，TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、血糖（GlU）、总蛋白（TP）、白蛋白（ALB）、球蛋白（GLOB）、白球比例（A/G）、尿素（UREA）、肌酐（Cr）、估算肾小球滤过率（eGFR）等实验室检查资料。应用SPSS 25.0软件进行统计学分析，FFA和SUA水平的相关性采用Spearman相关性分析和多元线性回归分析，FFA与中青年HUA发病风险的相关性采用多因素二元logistic回归分析。
结果与健康对照组比较，HUA组患者SUA、TC、TG、FFA、TP、ALB及UREA水平明显增高（P<0.05，P<0.01），年龄、BMI、Glu、HDL-C、LDL-C、GLOB、A/G、Cr、eGFR水平差异无统计学意义（P＞0.05）。中青年HUA患者的FFA与SUA水平呈正相关（r=0.22，P=0.015），进一步校正年龄、BMI、Glu、TC、TG、HDL-C、LDL-C、TP、ALB、GLOB、A/G、UREA、Cr、eGFR后，FFA与SUA水平仍独立相关（β=0.08，95%置信区间：0.04～0.13，P<0.001），且中青年HUA发病风险随着血清FFA三分位数分组水平增加而增加（比值比逐渐增大）。
结论中青年HUA患者的血清FFA水平升高，血清FFA水平与中青年HUA发病风险存在相关性。

Abstract:
Objective To investigate the relationship between serum free fatty acid (FFA) level and hyperuricemia (HUA) in young and middle-aged people.
Methods A total of 176 apparently healthy young and middle-aged males who underwent physical examination in Zhu Xianyi Memorial Hospital of Tianjin Medical University from March 2018 to March 2020 were randomly selected and divided into HUA group (n=117) and healthy control group (n=59) according to HUA diagnostic criteria. Their basic information such as age and body mass index (BMI), were collected, Laboratory test results of FFA, blood uric acid (SUA), total cholesterol (TC), triglyceride (TG), highdensity lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), blood glucose (GlU), total protein (TP), albumin (ALB), GLOB, white globulin ratio (A/G), UREA (UREA), creatinine (Cr), estimated glomerular filtration rate (eGFR) were analyzed with software SPSS 25.0. Spearman correlation analysis and multiple linear regression analysis were used to evaluate the correlation between FFA and SUA levels, and multivariate binary Logistic regression analysis was used to evaluate the correlation between FFA and the risk for HUA.
Results Compared with healthy control group, the levels of SUA, TC, TG, FFA, TP, ALB and UREA in HUA group were significantly higher (P<0.05, P<0.01). There were no significant differences in age, BMI, Glu, HDL-C, LDL-C, GLOB, A/G, Cr and eGFR levels between two groups (P>0.05). There was a positive correlation between FFA and SUA level in HUA group (r=0.22, P =0.015). After further adjustment for age, BMI, Glu, TC, TG, HDL-C, LDL-C, TP, ALB, GLOB, A/G, UREA, Cr and eGFR, FFA was still independently correlated with SUA level (β=0.08, 95% CI: 0.04-0.13, P<0.001), and the risk for HUA in young and middle-aged adults increased with the increase of serum FFA quintile level (odds ratio increased gradually).
Conclusion Serum FFA level increased in young and middle-aged adults with HUA, and serum FFA level was correlated with the risk for developing HUA in young and middle-aged adults.

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