1990-2021年全球视角下慢性阻塞性肺疾病负担特征及预测研究

Characteristics of chronic obstructive pulmonary disease burden during 1990−2021 and future trend worldwide

  • 摘要:
    目的 本研究旨在描述全球慢性阻塞性肺疾病(COPD)的负担,为COPD的防治提供依据。
    方法 基于全球疾病负担(GBD)2021数据定量描述1990-2021年分别处在不同等温线上的3组国家(中国和美国、南非和澳大利亚、伊拉克和葡萄牙)归因于非适宜温度的COPD早死所致寿命损失年(YLL)率,并比较了6个国家的变化趋势。 基于贝叶斯年龄–时期–队列模型预测这6个国家2022-2036年YLL率趋势。 使用来自21个GBD地区的数据,通过限制性立方样条和分位数回归分析社会人口指数(SDI)与YLL率的关系。
    结果 中国、美国、澳大利亚、伊拉克、葡萄牙、南非6个国家2021年非适宜温度导致COPD的年龄标准化YLL率分别为124.91/10万、63.57/10万、31.94/10万、31.38/10万、35.3/10万、72.31/10万。 低温比高温对COPD负担的影响更大。 6个国家中男性的YLL率均高于女性。 预测2022-2036年澳大利亚、葡萄牙和南非的年龄标准化YLL率呈上升趋势,其余国家呈下降趋势。 归因于非适宜温度COPD的YLL率较高的地区主要集中在SDI为0.39~0.70的地区。 YLL率与SDI拟合的分位数回归有意义是P25P75
    结论 在归因于非适宜温度的COPD疾病负担中,低温造成的负担更高,同时受性别和SDI的影响。 2022-2036年,除澳大利亚、葡萄牙和南非外其余国家由于非适宜温度导致COPD的YLL率呈下降趋势。

     

    Abstract:
    Objective To describe the global burden of chronic obstructive pulmonary disease (COPD) in the world, and provide evidence for the prevention and treatment of COPD.
    Methods Based on global burden of disease (GBD) 2021 data, the years of life lost (YLL) rate attributed to non-optimal temperature for COPD in three groups of countries at different isotherms (China and The United States of America, South Africa and Australia, Iraq and Portugal) from 1990 to 2021 were described, and the future trends in these six countries were compared. Based on the Bayesian age-period-cohort (BAPC) model, the trends of YLL rates in the six countries from 2022 to 2036 were predicted. By using data from 21 GBD regions, the relationship between the socio-demographic index (SDI) and YLL rates was analyzed with restricted cubic splines and quantile regression model.
    Results The age-standardized YLL rates of COPD attributable to non-optimal temperature in China, The United States of America, Australia, Iraq, Portugal and South Africa in 202 were 124.91/100000, 63.57/100000, 31.94/100000, 31.38/100000, 35.3/100000, and 72.31/100000, respectively. Low temperature had greater impact on COPD burden. Men had higher YLL rate compared with women in all six countries. It is predicted that the age standardized YLL rates from 2022 to 2036 would show upward trends in Australia, Portugal and South Africa and downward trends in other countries. The areas with higher YLL rates attributable to non-optimal temperature were mainly in regions with SDI values between 0.39 and 0.70. The quantile regression fitted with YLL rates and SDI was significant at P25 and P75.
    Conclusion In COPD burden attributable to non-optimal temperature, low temperature caused-burden had higher proportion. The burden were influenced by gender and SDI. In 2022−2036, the YLL rates of COPD attributable to non-optimal temperature would decrease in all other countries except Australia, Portugal and South Africa.

     

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