基于消费记录的诺如病毒感染暴发疫情回顾性队列溯源调查

Retrospective cohort study of norovirus infection outbreak based on consumption records

  • 摘要:
    目的 利用消费记录开展一起发生在A工厂的诺如病毒感染暴发疫情的回顾性溯源调查,为类似暴发疫情调查提供参考。
    方法 参照《诺如病毒感染暴发调查和预防控制技术指南(2015版)》开展现场流行病学调查和样本采样检测。 收集某年A工厂食堂进餐消费记录,利用消费记录开展回顾性队列溯源调查。
    结果 此次疫情共报告病例78例,罹患率为1.32%(78/5 890)。 其中8例隐性感染者为食堂工作人员,其余70例为工厂工人。 70例工人病例分布在2个厂区11个部门。 流行曲线呈间歇同源暴露模式,可能的暴露时间为某年10月15日晚上至17日中午,期间共7个餐次。 所有病例均无饮用生水习惯。 回顾性队列研究显示:到食堂就餐为危险因素相对危险度 (RR)=8.35,95%置信区间(CI):2.63~26.49)。 7个餐次中仅到餐饮X就餐为危险因素(RR=13.12,95%CI:5.22~32.93)。 7个可疑餐次中,16日中餐(RR=3.07,95%CI:1.64~5.73)和17日中餐(RR=2.21,95%CI:1.26~3.87)为可疑餐次;进一步叉生分析显示,16日中餐和17日中餐均为危险餐次。 实验室检测发现8例病例,以及餐饮X的3名厨师、5名切菜工诺如病毒GⅡ型阳性。 餐饮X餐具由切菜工、洗菜工、蒸菜工、杂工共11人负责清洗。
    结论 16日和17日中餐供餐为危险因素,餐饮X多名餐厨人员携带诺如病毒污染餐具可能是引起暴发的主要原因。 利用消费记录可以较好地完成诺如病毒感染暴发疫情的溯源调查。

     

    Abstract:
    Objective To introduce a retrospective tracing investigation of a norovirus outbreak at Factory A using consumption records, providing a reference for similar outbreak investigations.
    Methods Following the Technical Guidelines for norovirus Outbreak Investigation and Prevention and Control (2015 Edition), a field epidemiological investigation and sample testing were conducted. Consumption records from the Factory A canteen were collected and used for a retrospective cohort tracing investigation.
    Results A total of 78 cases were reported in this outbreak, with an attack rate of 1.32% (78/5890). Among them, 8 asymptomatic carriers were canteen staff, while the remaining 70 cases were factory workers. The 70 worker cases were distributed across 11 departments in 2 factory zones. The epidemic curve exhibited an intermittent common-source exposure pattern, with potential exposure occurring between the evening of the 15th and midday on the 17th, during a total of 7 meal periods. None of the cases had a habit of drinking raw water. The retrospective cohort study showed that dining at the canteen was a risk factor (RR=8.35, 95%CI: 2.63−26.49). Among the 7 meal periods, dining at Catering X was the only risk factor (RR=13.12, 95%CI: 5.22−32.93). Of the 7 suspected meal periods, lunch on the 16th (RR=3.07, 95%CI: 1.64−5.73) and lunch on the 17th (RR=2.21, 95%CI: 1.26−3.87) were identified as suspected meal periods. Further stratified analysis showed that both lunch on the 16th and lunch on the 17th were risk meals. Laboratory tests revealed that 8 cases, 3 chefs, and 5 vegetable cutters from Catering X were positive for norovirus GⅡ. The dishwashing of Catering X utensils was managed by 11 workers, including vegetable cutters, vegetable washers, steamers, and general workers.
    Conclusion Lunch services on the 16th and 17th were risk factors, and contamination of utensils by multiple Catering X kitchen staff carrying norovirus was likely the main cause of the outbreak. Consumption records can be effectively used to trace the source of norovirus outbreaks.

     

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