Objective To establish an indicaor system for the evaluation of interconnection and interoperability of infectious disease information system between medical instittion and disease prevention insttution, facilitate the establishment of intelligent infectious disease surveillance and early warning syatem and the development of new integration mechanism of medical service and disease prevention.

Methods The system framework and alternative indicator pool were determind through literature retrieval and other methods, 21 experts were invited for the two round assessments of indicator system with Delphi method, and hierarchical analysis was used to determine the indicator weights.

Results The final indicator system for the evaluatin of interconnection and interoperability of infectious disease information system between medical instittion and disease prevention insttution contain 5 first-level indicators, 20 second-level indicators, and 61 third-level indicators. The positive coefficient of experts in the two round assessments was 100.00%, the authority coefficient of experts was 0.86, the Kendall’s W coordination coefficient of all indicators in the two round assessments were 0.14 and 0.17, and the coefficients of variation were 0.15 and 0.13, respectively.The weights of the first-level indicators were 0.37 for planning, design and safety, 0.28 for support of data standards, 0.19 for informationization construction and management, 0.13 for content of infrmation share between medical institution and disease prevention instittution. and 0.04 for interconnection and interoperability benefits.

Conclusion An indicator system for the evalaution of interconnection and interoperability of infectious disease information system between medical institution and disease prevention institution was etblished in this sudy, which provide reference and framwork to improve the interconnection and interoperability of infectious disease information system between medical institution and disease prevention insttution for the intelligent infectious disease surveillance and early warnnig in China.