Abstract: In December 2024, a total of 70 infectious diseases were reported globally, affecting 236 countries and regions. Except for influenza, the top five infectious diseases affecting greatest number of countries and regions were Coronavirus disease 2019 (COVID-19) (236), mpox (127), dengue fever (34), cholera (28) and measles (22). The top five infectious diseases with highest case fatality rates were human infection with avian influenza A(H5N1) (48.20%), Marburg virus disease (22.70%), Lassa fever (16.30%), West Nile fever (8.60%) and Crimean-Congo haemorrhagic fever (7.80%). The top five infectious diseases with greatest number of deaths were COVID-19, dengue fever, cholera, mpox and malaria. The prevalent infectious diseases in Asia were COVID-19, cholera, dengue fever, mpox, Crimean-Congo hemorrhagic fever and poliomyelitis, the prevalent infectious diseases in Africa were COVID-19, cholera, yellow fever, Lassa fever, mpox, dengue fever and poliomyelitis, the prevalent infectious diseases in America were COVID-19, dengue fever, chikungunya fever and mpox, the prevalent infectious disease in Europe were COVID-19, mpox, West Nile fever and measles.