2018-2019年江苏省病毒性腹泻病原谱构成及流行特征分析

陈强 戚宇华 冷红英 吴昀 郭宏雄

陈强, 戚宇华, 冷红英, 吴昀, 郭宏雄. 2018-2019年江苏省病毒性腹泻病原谱构成及流行特征分析[J]. 疾病监测. doi: 10.3784/jbjc.202112130639
引用本文: 陈强, 戚宇华, 冷红英, 吴昀, 郭宏雄. 2018-2019年江苏省病毒性腹泻病原谱构成及流行特征分析[J]. 疾病监测. doi: 10.3784/jbjc.202112130639
Chen Qiang, Qi Yuhua, Leng Hongying, Wu Yun, Guo Hongxiong. Pathogen spectrum and epidemiological characteristics of viral diarrhea in Jiangsu[J]. Disease Surveillance. doi: 10.3784/jbjc.202112130639
Citation: Chen Qiang, Qi Yuhua, Leng Hongying, Wu Yun, Guo Hongxiong. Pathogen spectrum and epidemiological characteristics of viral diarrhea in Jiangsu[J]. Disease Surveillance. doi: 10.3784/jbjc.202112130639

2018-2019年江苏省病毒性腹泻病原谱构成及流行特征分析

doi: 10.3784/jbjc.202112130639
详细信息
    作者简介:

    陈强,男,浙江省温州市人,硕士,主管技师,主要从事疫苗可预防传染病相关研究,Email:414869257@qq.com

    通讯作者:

    郭宏雄,Tel:025–83759335,Email:hongxiongguo@yahoo.com

  • 中图分类号: R211;R512.5

Pathogen spectrum and epidemiological characteristics of viral diarrhea in Jiangsu

More Information
  • 摘要:   目的   了解2018—2019年江苏省病毒性腹泻的病原谱和流行特征,以更好地为病毒性腹泻的科学防控和临床治疗提供数据支撑。  方法   收集2018年11月至2019年10月江苏省哨点医院肠道门诊所有腹泻病例的新鲜粪便标本进行病毒核酸检测,使用χ2检验对标本阳性率结果进行统计分析。  结果   共收集2 486例腹泻病例,其中633份样本病毒核酸检测阳性,检出率为25.46%。 所有阳性样本中,诺如病毒和轮状病毒的占比分别为32.07%和25.43%,合计占比超过50%。 感染性腹泻高发年龄为3~5岁(29.04%),高发季节为夏季(28.59%)和秋季(27.18%),外来人群的病毒检出率(45.76%)高于本地人群(23.33%)(χ2=56.618,P<0.001)。  结论   建议将0~5岁学龄前儿童作为病毒性腹泻防控的重点人群,同时加强夏秋季节的病毒性腹泻防控工作,并扩大针对外来流动人口的健康宣教力度。
  • 图  1  江苏省病毒性腹泻中诺如病毒与轮状病毒月份分布

    Figure  1.  Monthly distributions of norovirus and rotavirus detections in viral diarrhea cases in Jiangsu

    表  1  病毒核酸检测所需引物及探针

    Table  1.   Primers and probes for detection of virus nucleic acid

     病毒种类引物荧光探针
    RV F- ACC ATC TWC ACG TRA CCC TC
    R- CAC ATA ACG CCC CTA TAG CC
    HEX- ATG AGC ACA ATA GTT AAA AGC TAA CAC TGT CAA
    NoVGⅠ型 F- CGY TGG ATG CGN TTY CAT GA
    R- CTT AGA CGC CAT CAT CAT TYA C
    JOE- AGA TYG CGA TCY CCT GTC CA
    NoVGⅡ型 F- CAR GAR BCN ATG TTY AGR TGG ATG AG
    R- TCG ACG CCA TCT TCA TTC ACA
    FAM- TGG GAG GGC GAT CGC AAT CT
    EV71 F- TGA TTG AGA CAC GST GTG TYC TTA
    R- CCC GCT CTG CTG AAG AAA CT
    HEX- TCG CAC AGC ACA GCT GAG ACC ACT C
    Cox A16 F- GGG AAT TTC TTT AGC CGT GC
    R- CCC ATC AAR TCA ATG TCC C
    FAM- ACA ATG CCC ACC ACG GGT ACA CA
    AstV F-TCT YAT AGA CCG YAT TAT TGG
    R- TCA AAT TCT ACA TCA TCA CCA A
    ROX- CCC CAD CCA TCA TCA TCT TCA TCA
    AstV F- GTA ACA SWW GCC TCT GGG SCC AAA AG
    R- GGC CCC WGR TCA GAT CCA YAG T
    VIC- CCT RYG GGT ACC TYC WGG GCA TCC TTC
    SaV F- CAG GCT CTC GCC ACC TAC
    R- CCC TCC ATY TCA AAC ACT AWT TT
    FAM- TGG TTC ATA GGT GGT RC
    AdeV F- GCC ACG GTG GGG TTT CTA AAC TT
    R- GCC CCA GTG GTC TTA CAT GCA
    CAT C
    Atto647- TGC ACC AGA CCC GGG CTC AGG TAC TCC GA
    注:F. 正向引物;R. 反向引物
    下载: 导出CSV

    表  2  江苏省病毒性腹泻病原谱构成情况

    Table  2.   Pathogenic spectrum of viral diarrhea in Jiangsu

    病毒类型阳性阳性率(%)构成比(%)
    NoV2038.1732.07
    RV1616.4825.43
    EV71953.8215.01
    CoxV16742.9811.69
    AstV431.736.79
    AdeV361.455.69
    PeV120.481.90
    SaV90.361.42
     合计63325.46100.00
    下载: 导出CSV

    表  3  江苏省病毒性腹泻核酸阳性病例分布情况

    Table  3.   Distribution of viral diarrhea cases in Jiangsu

    影响因素阳性病例数阳性率(%)χ2P
    性别男性3161 27424.800.5980.461
    女性3171 21226.16
    地区无锡20482324.790.8800.644
    徐州21681126.63
    镇江21385225.00
    年龄组(岁) 0~16059027.1219.7300.001
    3~24183029.04
    6~13354424.45
    10~7134520.58
    15~2817715.82
    户籍本地5252 25023.3356.618< 0.001
    外地10823645.76
    季节a春季7635021.7120.052< 0.001
    夏季27596228.59
    秋季20675827.18
    冬季7641618.27
    注:a. 我国春季为3-5月,夏季为6-8月,秋季为9-11月,冬季为12月至次年2月
    下载: 导出CSV
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  • 收稿日期:  2021-12-13
  • 网络出版日期:  2022-06-20

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