Objective  To study the morality and life loss of injury death in Huzhou, Zhejiang province, and provide scientific evidence for the prevention and control of injury.

  Methods  The injury death data in residents in Huzhou from 2014 to 2020 were collected and the data were classified according to the international classification of diseases, 10^th edition(ICD-10); The mortality and death cause constituent were calculated, and the mortality trend was evaluated by using χ² test. The average years of life lost (AYLL) and potential years of life lost rate (PYLLR) were calculated, and the trend of AYLL and PYLLR were evaluated by using annual percent change (APC).

  Results  The average mortality rate of injury was 69.82/100 000 in residents in Huzhou during 2014–2020, which showed a upward trend year by year (trend χ²＝244.537, P＜0.001). The injury mortality was higher in males than in females ( χ²＝233.771, P＜0.001). The first five injury death causes were accidental fall, traffic accident, shipping accident except motor vehicle, suicide, drowning. The mortality rates of deaths caused by accidental fall in entire population and drowning in females increased with year (trend χ²＝474.799, P＜0.001, trend χ²＝6.711, P＜0.05). Drowning was the major death cause in age group 0–14 years, traffic accident was the major death cause in age group 15–64 years and accidental fall was the major death cause in age group >65 years. The average years of life lost by injury was 18.15 years, the potential years of life lost rate was 5.67‰, the first three leading injury related death causes were traffic accident, shipping accident except motor vehicle and suicide.

  Conclusion  Injury has become one of major death causes in Huzhou, causing great loss of life expectancy, targeted prevention and control measures for traffic accident, accidental fall, drowning and other key injuries should be conducted to reduce the burden of injury effectively.