马尔堡病毒病的流行特征及其临床表现与预防控制

杜珊珊 邓雪飞 黄晓霞 李建东

杜珊珊, 邓雪飞, 黄晓霞, 李建东. 马尔堡病毒病的流行特征及其临床表现与预防控制[J]. 疾病监测, 2022, 37(6): 832-838. doi: 10.3784/jbjc.202203060673
引用本文: 杜珊珊, 邓雪飞, 黄晓霞, 李建东. 马尔堡病毒病的流行特征及其临床表现与预防控制[J]. 疾病监测, 2022, 37(6): 832-838. doi: 10.3784/jbjc.202203060673
Du Shanshan, Deng Xuefei, Huang Xiaoxia, Li Jiandong. Marburg virus disease: epidemiology, clinical features, and prevention[J]. Disease Surveillance, 2022, 37(6): 832-838. doi: 10.3784/jbjc.202203060673
Citation: Du Shanshan, Deng Xuefei, Huang Xiaoxia, Li Jiandong. Marburg virus disease: epidemiology, clinical features, and prevention[J]. Disease Surveillance, 2022, 37(6): 832-838. doi: 10.3784/jbjc.202203060673

马尔堡病毒病的流行特征及其临床表现与预防控制

doi: 10.3784/jbjc.202203060673
基金项目: 国家科技重大专项(No. 2016ZX10004222–002)
详细信息
    作者简介:

    杜珊珊,女,山东省青岛市人,实习研究员,主要从事病毒性出血热相关病毒研究,Email: 840369768@qq.com

    邓雪飞,男,江西省南昌市人,在读研究生,主要从事病毒性出血热相关病毒研究,Email:2640687668@qq.com

    通讯作者:

    李建东,Tel:010–58900824, Email: ldong121@126.com

  • 中图分类号: R211; R511; R373

Marburg virus disease: epidemiology, clinical features, and prevention

Funds: This study was supported by the National Science and Technology Major Project(No. 2016ZX10004222–002)
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  • 摘要:   目的  总结分析马尔堡病毒病的流行特征、临床表现、实验室检测和预防控制措施研究现状。  方法  通过对PubMed数据库、必应学术收索、世界卫生组织发布信息等与马尔堡病毒病的流行情况有关的文献和资料的收集分析,筛选有明确分离时间和地区的马尔堡病毒基因组序列,进行系统进化分析,分析病原学特征。  结果  马尔堡病毒是对人类最致命的病原体之一,其流行威胁的地区呈现不断扩大的趋势,人们对该病的认识主要源自3次较大规模的暴发流行,病毒遗传进化具有较高稳定性,两个主要分支间差异约为20%,分支内病毒基因组序列差异约为7%,但蝙蝠等自然宿主中同时流行的毒株具有丰富的多样性,给基于核酸的分子诊断带来挑战。  结论  马尔堡病毒病流行形势与危害被低估,应引起人们警惕和关注,加大特异性防控和治疗措施的研发投入,提高病例识别和防控能力。
  • 图  1  马尔堡病毒全基因组系统进化树分析

    注:使用MEGA 11软件通过使用最大似然法和Tamura-Nei模型MARV全基因组序列进行分析15

    Figure  1.  Phylogenetic analysis of the whole genome sequences of Marburg virus

    表  1  1967年以来马尔堡病毒引发人群感染的情况

    Table  1.   Outbreaks of Marburg virus disease since 1967

    年代地区国家可能感染模式死亡数/发病数病死率(%)
    1967马尔堡德国处理乌干达进口的受感染的非洲绿猴5/2421
    1967法兰克福德国处理乌干达进口的受感染的非洲绿猴2/633
    1967贝尔格莱德塞尔维亚处理乌干达进口的受感染的非洲绿猴0/221
    1975约翰内斯堡南非两名澳大利亚人在津巴布韦旅行,可能
    因居住在有蝙蝠的房间或参观西诺亚洞
    穴(现为奇诺伊洞穴)而感染,在南非
    就医时导致一名护士发生继发感染
    1/333
    1988科尔佐沃前苏联实验室针刺感染1/1100
    1990科尔佐沃前苏联不明原因实验室感染0/10
    1990瑞典瑞典在肯尼亚旅行归国后,
    被诊断为疑似病例。
    0/10
    1998-2000Durba,Watsa刚果民主共和国可能因在Goroumbwa洞穴开采金矿 ,
    导致同时发生多次独立的或相互重叠的
    暴发疫情
    128/15483
    2004-2005尤格安哥拉原因不明329/37488
    2007卡穆文奇(Kamwenge)乌干达北坂洞金矿开采工人中暴发,
    发病5例,确诊4例,死亡1例
    1/425
    2008科罗拉多美国参观乌干达马拉马甘博森林中的蟒蛇洞0/10
    2008莱顿市荷兰参观乌干达马拉马甘博森林中的蟒蛇洞1/1100
    2012伊班达和卡巴莱乌干达原因不明15/2658
    2014坎帕拉乌干达原因不明1/1100
    2017乌干达乌干达原因不明3/933
    2021盖凯杜几内亚原因不明1/1100
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  • 收稿日期:  2022-01-06
  • 网络出版日期:  2022-03-25
  • 刊出日期:  2022-07-14

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