一例Y群ST-23克隆群脑膜炎球菌肺炎患者的病例报告

贺晴 张欣强 陆小玲 景钦隆 邵晓萍 刘美真

贺晴, 张欣强, 陆小玲, 景钦隆, 邵晓萍, 刘美真. 一例Y群ST-23克隆群脑膜炎球菌肺炎患者的病例报告[J]. 疾病监测.
引用本文: 贺晴, 张欣强, 陆小玲, 景钦隆, 邵晓萍, 刘美真. 一例Y群ST-23克隆群脑膜炎球菌肺炎患者的病例报告[J]. 疾病监测.
He qing, Zhang xingqiang, Lu xiaoling, Jing Qinlong, Shao Xiaoping, Liu Meizhen. A pneumonia case caused by Neisseria meningitides serogroup Y ST-23 clonal complex[J]. Disease Surveillance.
Citation: He qing, Zhang xingqiang, Lu xiaoling, Jing Qinlong, Shao Xiaoping, Liu Meizhen. A pneumonia case caused by Neisseria meningitides serogroup Y ST-23 clonal complex[J]. Disease Surveillance.

一例Y群ST-23克隆群脑膜炎球菌肺炎患者的病例报告

基金项目: 广州市卫生和计划生育科技项目(No. 20181A011056)
详细信息
    作者简介:

    贺晴,女,湖南省湘乡市人,硕士,主管医师,主要从事疫苗可预防传染病的防控,Email:heqingnzzz@foxmail.com

    通讯作者:

    邵晓萍,Tel:020-31051182,Email:465113619@qq.com

    刘美真,Tel:020-31051226,Email:gz-lmz@163.com

  • 中图分类号: R211; R378

A pneumonia case caused by Neisseria meningitides serogroup Y ST-23 clonal complex

Funds: This study was supported by the Medical Health Technology Project for Guangzhou (No. 20181A011056)
More Information
  • 摘要:   目的   了解广东省广州市一例脑膜炎奈瑟菌引起的肺炎病例的流行病学、病原学以及临床特征。  方法   收集病例的临床诊疗经过及流行病学调查资料,对医院分离的菌株进行生化鉴定、乳胶凝集、血清分群、核酸聚合酶链式反应(PCR)分型、全基因组测序及体外药敏试验,确定脑膜炎奈瑟菌的分群及基因型。  结果   患者临床症状为咽痛、发热、气促、精神疲倦等,无头痛、恶心、意识障碍,无脑膜炎刺激征,全身未见出血点、皮疹。胸部计算机体层摄影术(CT)示肺部感染。从病例血培养中分离到的菌株经鉴定为Y群脑膜炎奈瑟菌, 基因组测序显示其序列型为ST-1655(属于ST-23克隆群)。该菌株对青霉素、头孢噻肟、头孢曲松等10种抗生素敏感。  结论   该病例是广州市首例Y群脑膜炎奈瑟菌引起的肺炎病例,基因分型与广东省分离到的境外流行株一致,应警惕ST-23克隆群的潜在危害,同时应加强对其他脑膜炎球菌性疾病的监测工作。
  • 图  1  患者胸部计算机体层摄影术

    Figure  1.  Patients’chest computer tomography

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  • 收稿日期:  2021-02-08

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