Abstract: In May 2022, a total of 66 infectious diseases were reported globally, affecting 233 countries and regions. Except for influenza, the top five infectious diseases affecting greatest number of countries and regions were COVID-19 (233), monkeypox (36), dengue fever (31), measles (24) and cholera (11). The top five infectious diseases with highest case fatality rates were Ebola virus disease (100.0%), Middle East Respiratory Syndrome (34.4%), Crimean-Congo hemorrhagic fever (22.2%), Lassa fever (19.8%) and monkeypox (4.0%). The top five infectious diseases with greatest number of deaths were COVID-19, malaria, cholera, dengue fever and measles. The prevalent infectious diseases in Asia were COVID-19, dengue fever and cholera, the prevalent infectious diseases in Africa were COVID-19, Ebola virus disease, cholera, yellow fever, Lassa fever, malaria and monkeypox, the prevalent infectious diseases in America were COVID-19, dengue fever, chikungunya fever and Zika virus disease, the prevalent infectious disease in Europe were COVID-19, monkeypox and acute hepatitis of unknown aetiology.