脊髓灰质炎Ⅰ型重组病毒病例的流行病学研究
A Study on the Epidemiology of Poliomyelitis infectedwith Recombinant strain of Poliovirus Type 1
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摘要: 1989~1991年在河北省发生了脊髓灰质炎Ⅰ型自然重组株病毒的流行(为脊髓灰质炎野病毒和疫苗病毒的基因重组),对重组病毒麻痹病例进行了调查,已发现的病例分布在河北省的六个市地,占省辖市地数的50%,病例全部为4岁以下农村儿童,发病时间以四月为高峰,85%病例为没有接种或没有全程接种脊髓灰质炎疫苗,病例的临床症状主要是发热、腹泄、肢体麻痹,严重病例可发生呼吸困难。但有半数病例在60天肢体麻痹恢复。Abstract: A Study on the epidemiology of poliomyelitis infected with recombinant strain of po- liovirus type 1 was reported. The recombinant poliovirus type 1 was recombinanted by wild strain and Sabin strain. Totally 1 4 cases was under 4 years old and distributed in the rural areas of 6 cities or prefectures. 85 percent of cases had not vaccinated with poliovaccine. The main symptoms were fever ,diarrhoea and paralysis , 50% of them were recovered less than 60 days.