李辉, 李荣成, 廖苏苏, 李艳萍, 曾宪嘉, 龚健, 潘利, 张孔来. 壮族地区新生儿乙型肝炎疫苗免疫九年保护效果及免疫后HBsAg阳性者原因分析[J]. 疾病监测, 1998, 13(2): 45-49. DOI: 10.3784/j.issn.1003-9961.1998.2.45
引用本文: 李辉, 李荣成, 廖苏苏, 李艳萍, 曾宪嘉, 龚健, 潘利, 张孔来. 壮族地区新生儿乙型肝炎疫苗免疫九年保护效果及免疫后HBsAg阳性者原因分析[J]. 疾病监测, 1998, 13(2): 45-49. DOI: 10.3784/j.issn.1003-9961.1998.2.45
Li Hui et al, . Long-term Efficacy of Hepatitis B Vaccination in Infants in Zhuang Minority Area[J]. Disease Surveillance, 1998, 13(2): 45-49. DOI: 10.3784/j.issn.1003-9961.1998.2.45
Citation: Li Hui et al, . Long-term Efficacy of Hepatitis B Vaccination in Infants in Zhuang Minority Area[J]. Disease Surveillance, 1998, 13(2): 45-49. DOI: 10.3784/j.issn.1003-9961.1998.2.45

壮族地区新生儿乙型肝炎疫苗免疫九年保护效果及免疫后HBsAg阳性者原因分析

Long-term Efficacy of Hepatitis B Vaccination in Infants in Zhuang Minority Area

  • 摘要: 乙肝免疫后9年,1183名1~9岁广西壮族儿童的保护性抗体阳性率为43.8%,从免后1岁的87.9%下降为37.1%,但HBsAg阳性率1.6%,未见随免疫年限延长而显著升高,疫苗保护率为88.6%。免疫后儿童HBsAg阳性89.1%归因于母亲HBsAg阳性。本研究结果表明乙肝疫苗免疫后9年不必加强免疫,只有采用高剂量免疫策略才能进一步降低HBsAg阳性率。

     

    Abstract: 1183 children aged 1-9 years immunized with hepatitis B vaccine 9 years later were randomly sampled to evaluate the efficacy of a low dose immunization started in 1987 in a Zhuang Minority Area.The crude anti-HBs positive rate was 43.8%,and the age-specific rates were ranged from 87.9% (lst year )to 37.1% (9th year).The crude HBsAg positive rate was 1.6% and the efficacy of vaccination against B was 86.6%.The results showed that there was no evidence of necessity for revaccination against hepatitis B at present,and the high-dose immunization straregy should be recommended for further declining HBsAg posi-tive rate in the area.

     

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