Abstract: Objective This analysis was to have a better understanding of HIV infection and related risk factors among drug users in Donggan and to provide basis for intplementing intervention work Methods 1 978 drug users who underwent compulsory drug rehabilitation in Donggan drug rehabilita tion center from January to November in 2004 were inspected using serological HIV antibody test and de mographic and ethological data of subjects were derived from uniform questionnaire investigation，and EPIDATA 3.0 and STATA 8.0 were used for statistical analysis Results The rate of HIV infection a mong drug users in Donggan was 6.14％，of which the infection rate of local drug users was substantially lower than migrants，and those who shared syringes and needles had a remarkably higher infection rate than those who did not；among drug users，the rate of injection was 63.51％，of which the rate of shar ing injection equipments was 46.43％；commercial sexual behavior accounted for 55.16％ in drug users，of which only 15.24％ used condom each time. Conclusion There has been a great increase of infec tion rate among drug users in Donggan and such risk factors as sharing syringes and needles as well as commercial sexual behavior still exist in drug users，therefore intarvention measures including Methadone replacement therapy and 100％ condom strategy shonld be popularized among drug users.