Abstract: Objective This study was made to probe into the differences in epidemic situation of STD reported by different epidemic situation report systems and the reasons for these differences．Methods Comparative and collective analysis was conducted on the data of epidemic situation of STD in 2004 selected from China disease surveillance information report management system in Xuhui District (short for”direct report through network”)，China disease report management infor-marion system (short for”CAMPs”) and STD Epidemic situation management system in Shanghai (short for STDs in Shanghai)．Results Among three epidemic situation report systems，STDs in Shanghai reported the most cases totaled 1970 with STD in the category of notifiable Type A and B STD，84 cases more than that of Direct report through network system and 206 cases more than CAPMs．Except for the number of Syphilis cases reported，Direct report through network system reported fewer cases with other types of STD than other two systems．There were significant dif-ferences among three systems in the number of AIDS cases reported．In addition，among three surveillance STD detected and reported in this district，Direct report through network system report-ed fewer cases with all types of STD than cases reported by STDs in Shanghai．Conclusion There were significant statistical variances and low credibility among epidemic situation report sys-terns in Xuhui District，which may be related to not check in repeated cards，failure to report and not report of surveillance STD，lack of information communication among systems，incomplete in-put，omission or even errors in data entry