Abstract: Objective　The study was conducted to analyze the epidemiological characteristics of syphilis in Guangxi from 1997 to 2007 and to determine the influential factors of the endemic of syphilis. Methods　Retrospective analysis was performed based on the epidemiological data of syphilis from 1997-2007. Results　A total of 92 179 syphilis cases were reported in Guangxi from 1997 to 2007, the average annual reported incidence being 17.80/lakh. The lowest reported incidence was 2.88/1lakh in 1997, the highest 48.20/lakh in 2007. There were 42 827 cases at stage Ⅰ, accounting for 46.46%; 23 481 cases at stage Ⅱ, accounting for 25.47%; and 364 at stage Ⅲ, accounting for 0.39%; besides were 3747 congenital syphilis cases, accounting for 4.07% and 21 760 latent syphilis cases, accounting for 23.61%. 62.54% of the affected patients were aged between 20 and 39 years. Conclusion　Guangxi has been a syphilis and AIDS prevailing area. The incidence of syphilis was slightly higher in women than in men with significantly greater number of low aged female patients. Syphilis cases has been infiltrating from urban areas to rural ones.