Abstract: Objective　The present study was conducted to identify the type of Vibrio cholerae and to analyze the antibiotic resistance of a food-borne outbreak epidemic situation of cholera，so as to provide the references for prevention and control of cholera. Methods　Patients, close contacts and the environmental samples were collected; type identification was done according to Manual for the Prevention and Control of Cholera(5th edition); then the antibiotic resistance of Vibrio cholerae to 20 different common clinic antibiotics were tested by the automatic microorganism identification machine. Results A total of 45 samples were collected. Among those samples, O1 group of El Tor Vibrio cholerae sero type Inaba 1d was detected from 9 patients and 1 environment sample, while it was not detected from the samples of close contacts; The antibiotic resistance of these 10 isolates to the 20 kinds of antibiotics was completely consistent. The samples were 100％ resistant to sulfamethoxazole only (5%, 1/20) of the antibiotics. High drug susceptibility of the samples was found to 11 kinds of antibiotics such as Ceftriaxone and Gentamicin(55%, 11/20); the middle-susceptibility was found to 8 kinds such as Ampicillin(40%, 8/20). Conclusion　The type of Vibrio cholerae that caused this food-borne outbreak epidemic situation of cholera was O1 group of El Tor Vibrio cholerae sero type Inaba 1d. Ceftriaxone, Gentamicin could be drugs of choice for the treatment and prevention, but sulfamethoxazole could not be used.