Abstract: Objective To understand the prevalence of dyslipidemia among adults in Zhejiang and provide evidence for the development of the prevention and control measure. Methods The study subjects were selected among local redidents aged 18 years by multi stage stratified cluster random sampling to conduct blood lipids detection. Results Totally 17 437 persons were surveyed, The adjusted prevalence of dyslipidemia was 49.19% (the crude prevalence: 49.86%). The prevalence in males (54.29%) was significantly higher than that in females (43.80%). The difference between urban area and rural area had no statistically significance. The adjusted prevalence was 50.07% in age group 18-44 years, 49.33% in age group 45-59 years and 45.87% in age group60 years. The prevalence of dyslipidemia in young people was high. The prevalence of low high-density lipoprotein cholesterol (HDL-C) was highest (42.28%) among different types of dyslipidemia and was as high as 51.70% in young males. The prevalence of abnormal triglyceride was 23.08% (the rate of high triglyceride: 12.14% and the rate of high triglyceride at cut off value: 10.94%). The prevalence of cholesterolemia at cut off value (10.42%) was 5.4 times higher than that of cholesterolemia (1.93%) Compared with the result of a study in 2002, the standardized of dyslipidemia increased in Zhejiang, especially in youth males. The study also found that the awareness of dyslipidemia was only 11.25%, the young group was characterized with high prevalence but low awareness. Conclusion Nearly half of the adults in Zhejiang are suffering from dyslipidemia. Low HDL-C accounted for the major part, and dyslipidemia is more prevalent in young people than before. It is necessary to increase the awareness of dyslipidema in local population and conduct active intervention to prevent dyslipidema.