Abstract: Objective To understand the epidemiological characteristics of hand foot and mouth disease (HFMD) in Baoji, Shaanxi prrovince, from 2008 to 2012 and provide evidence for the prevention and control of HFMD. Methods The analysis was condcuted on the incidence data of HFMD in Baoji during this period by using SPSS 12.0 software. Results A total of 12 469 HFMD cases were reported, including 90 severe cases and 10 deaths. The average annual incidence was 66.25/lakh. The incidence peak was during May-July. The disease mainly occurred in age group 1-4 years, especially in those aged 1 year. Most cases were caused by EV71 or Cox A16, but most severe cases were caused by EV71. Conclusion The incidence of HFMD increased year by year in Baoji, it is necessary to take comprehensive measures to prevent and control HFMD.