Abstract: Objective To understand the temporal spatial distribution of hemorrhagic fever with renal syndrome (HFRS), and the relationship between the temporal spatial clustering of HFRS and different factors, such as meteorological factors and rodent biological characteristics, in coastal area of Yancheng, Jiangsu province. Methods The incidence data, population data and meteorological data in coastal area of Yancheng from 2005 to 2014 were collected, and rodent density surveillance was conducted from April 2011 to December 2014. The temporal spatial distribution of HFRS were analyzed statistically. The relationship between the temporal spatial distribution of HFRS and the factors of rodent density and meteorology were evaluated with Pearson correlation analysis. Results The incidence of HFRS increased gradually from 2005 to 2014, which was highest in 2014(2.83/lakh). The incidence peak of HFRS was in winter. HFRS mainly occurred in Dafeng, Dongtai. The incidences in Haifeng farm, Shanghai farm, Eastern Sichuan farm of Dafeng and in Xincao farm of Dongtai were high. Two clustering of HFRS cases might occurred from 2005 to 2014, which were in Xincao farm from December 2010 to December 2014 and in Shanghai farm and Haifeng farm from November 2009 to December 2011. Apodemus agrarius was the predominant rodent species, accounting for 89.19%.The incidence peak of HFRS was consistent with the density peak of rodents. Temperature and rainfall peaks were observed before each incidence peak of HFRS. Pearson correlation analysis indicated that only temperature was correlated with the incidence of HFRS. Conclusion The area with high HFRS incidence exists in coastal area of Yancheng, it is necessary to strengthen the surveillance of HFRS in this area.