Abstract: Objective To analyze the epidemiological characteristics of acute flaccid paralysis (AFP) in children aged 15 years in Huzhou, Zhejiang province, and explore measures for AFP control and prevention. Methods Descriptive epidemiological analysis was conducted on the related data of AFP cases in Huzhou from 2004 to 2016.The risk factors of paralysis sequela were analyzed with univariate and multivariate non-conditional logistic regression model. Results A total of 128 AFP cases were reported in children aged 15 years in Huzhou during 2004-2016.The cases were mainly sporadic and the average annual incidence was 2.32/100 000. The annual peaks were in January and March and during August-October and the incidence was highest in age group 0-4 years. The gender ratio was 2.2:1. The enterovirus isolation rate was 7.81%. The incidence of residual paralysis 60 days after onset was 10.16%. The results of multivariate non-conditional logistic regression analysis showed that the risk factors for residual paralysis included age1 year and abnormal deep tendon reflex. Conclusion It is necessary to take effective measures to reduce the incidence of residual paralysis in AFP cases,including improving OPV immunization, strengthening clinical doctor training, health education in children and timely symptomatic treatment of severe cases.