Abstract:
Objective To analyze the antibiotic use in recent years in our hospital, analyze its influence on the prevalence of drug resistance of Escherichia coli and Klebsiella pneumoniae and provide guidance for the reasonable clinical use of antibiotics and the control and decrease of bacterial drug-resistance.
Methods The use frequency and use dose of antibiotics, and the drug resistance level of E. coli and K. pneumoniae isolated in our hospital from 2013 to 2017 were investigated.
Results The antibiotic use dose (AUD) increased year by year from 2013 to 2015 and decreased in 2016 in our hospital. According to the analysis of defined daily dose (DDD), the drug resistant rate of E. coli was positively correlated with the use frequencies of ceftazidime and cefuroxime, but negatively correlated with the use frequencies of other antibiotics. While the drug resistance rate of K. pneumoniae was obviously positively correlated with the use frequencies of meropenem and levofloxacin (r=0.980, P=0.003 and r=0.902, P=0.036), and positively correlated with use frequencies of ceftazidime, cefepime, gentamicin and cefoperazone/sulbactam, but negatively correlated with use frequencies of cefuroxime, imipenem and piperacillin/tazobactam.
Conclusion The use frequencies of commonly used antibiotics had certain relationship with the drug resistance of E. coli and K. pneumoniae, especially the relationship between the high frequency uses of meropenem and levofloxacin and the drug resistance of K. pneumoniae, to which close attention should be paid.