Abstract: In February 2022, a total of 59 infectious diseases were reported globally, affecting 229 countries and regions. Except for influenza, the top five infectious diseases affecting greatest number of countries and regions were COVID-19 (229), dengue fever (28), measles (16), cholera (9) and poliomyelitis (9). The top five infectious diseases with highest case fatality rates were Rift Valley fever (50.0%), Crimean-Congo haemorrhagic fever (33.3%), Lassa fever (19.1%), anthrax (16.7%) and monkeypox (5.8%). The top five infectious diseases with greatest number of deaths were COVID-19, malaria, measles, Lassa fever and dengue fever. The prevalent infectious diseases in Asia were COVID-19 and dengue fever, the prevalent infectious diseases in Africa were COVID-19, cholera, yellow fever, Lassa fever, malaria, measles and poliomyelitis, the prevalent infectious diseases in America were COVID-19, dengue fever and chikungunya fever, the prevalent infectious disease in Europe was COVID-19.