Objective  To understand the prevalence of hyperuricemia in adults in Hainan province and identify its influencing factors.

  Methods  In this study, 36 administrative villages/committees in 2 urban areas and 4 rural areas in Hainan were selected for the survey by multi-stage cluster random sampling. Adults in each village or community randomly and equally selected as study subjects according to inclusion and exclusion criteria. The subjects all received questionnaire survey, body measurement and laboratory test. The results were statistically analyzed with software SPSS 26.0.

  Results  A total of 3604 subjects were included in this study, and the average serum uric acid level was (325.19±87.22) μmol/L, the level was higher in men than in women (F=897.240, P<0.05) and in urban residents than in rural residents (F=24.385, P<0.05). The crude prevalence rate of hyperuricemia was 14.21%, and the weighted adjusted prevalence rate was 15.82%. The results of unconditional logistic regression analysis showed that being women confidence interval (OR)=0.135, 95% confidence interval (CI): 0.101–0.181) was associated with reduction of hyperuricemia risk, and age ≥60 years (OR=1.388, 95%CI: 1.017–1.895), the frequency of drinking less than 3 d per month (OR=1.384, 95%CI: 1.044–1.834), 1–4 d per week (OR=1.452, 95%CI: 1.026–2.055), 5–7 d per week (OR=1.726, 95%CI: 1.278–2.330), overweight (OR=1.962, 95%CI: 1.189–3.238) or obesity (OR=3.088, 95%CI: 1.700–5.609) were associated with increase of hyperuricemia risk. In addition, the hyperuricemia patients complicated with hyperglycemia, dyslipidemia, hypertension, overweight or obesity accounted for 63.48%, 50.20%, 46.09% and 43.16% respectively.

  Conclusion  The level of serum uric acid and the prevalence of hyperuricemia in adults in Hainan were higher than the national average, and most hyperuricemia patients were complicated with multiple forms of metabolic syndrome.