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高慧, 万金豹, 朱旭婷, 姜玉, 庄建林, 王英全, 吴施瑜, 钱君秋, 钱莉娜, 王鑫, 张磊, 吴萃. 不同体质指数下甘油三酯–腰围表型与糖尿病患病风险的关联性研究[J]. 疾病监测, 2023, 38(9): 1116-1120. DOI: 10.3784/jbjc.202211130500
引用本文: 高慧, 万金豹, 朱旭婷, 姜玉, 庄建林, 王英全, 吴施瑜, 钱君秋, 钱莉娜, 王鑫, 张磊, 吴萃. 不同体质指数下甘油三酯–腰围表型与糖尿病患病风险的关联性研究[J]. 疾病监测, 2023, 38(9): 1116-1120. DOI: 10.3784/jbjc.202211130500
shu
Gao Hui, Wan Jinbao, Zhu Xuting, Jiang Yu, Zhuang Jianlin, Wang Yingquan, Wu Shiyu, Qian Junqiu, Qian Lina, Wang Xin, Zhang Lei, Wu Cui. Association between triglyceridemic waist phenotype and risk for diabetes in people in different body mass index groups[J]. Disease Surveillance, 2023, 38(9): 1116-1120. DOI: 10.3784/jbjc.202211130500
Citation: Gao Hui, Wan Jinbao, Zhu Xuting, Jiang Yu, Zhuang Jianlin, Wang Yingquan, Wu Shiyu, Qian Junqiu, Qian Lina, Wang Xin, Zhang Lei, Wu Cui. Association between triglyceridemic waist phenotype and risk for diabetes in people in different body mass index groups[J]. Disease Surveillance, 2023, 38(9): 1116-1120. DOI: 10.3784/jbjc.202211130500
shu

不同体质指数下甘油三酯–腰围表型与糖尿病患病风险的关联性研究

Association between triglyceridemic waist phenotype and risk for diabetes in people in different body mass index groups

    摘要
  • 摘要:
      目的  分析不同体质指数（BMI）下甘油三酯–腰围表型与糖尿病前期及糖尿病患病的关联，为该人群的肥胖健康管理提供科学依据。
      方法  基于2016—2020年上海市长宁区和宝山区开展的“心血管病高危人群早期筛查与综合干预”子项目的初筛资料，采用问卷调查、体格检查和实验室检测等方法收集分析基本人口学信息、生活方式、既往疾病用药史、身高、体质量、腰围，以及血糖血脂等，采用多因素logistic回归分析甘油三酯–腰围分型与糖尿病及糖尿病前期患病风险的关联。
      结果  共纳入研究对象24 318人，其中正常组（甘油三酯正常且无腹型肥胖）11 536人，单纯腹型肥胖组5 650人，单纯高甘油三酯组3 745人，高甘油三酯–腹型肥胖组（HTWC）3 387人。 Logistic回归分析显示，HTWC与糖尿病前期及糖尿病的患病风险有独立于BMI的显著关联。 正常体质量人群中，HTWC组糖尿病［比值比（OR）=3.23，95%置信区间（CI）：2.44～4.25］和糖尿病前期（OR=1.46，95%CI：1.15～1.86）的患病风险均显著高于对照组；在超重人群中，HTWC组糖尿病（OR=3.24，95%CI：2.67～3.96）和糖尿病前期（OR=1.55，95%CI：1.34～1.80）的患病风险显著高于对照组；在肥胖人群中，HTWC组糖尿病（OR=2.23，95%CI：1.32～3.95）和糖尿病前期（OR=1.43，95%CI：0.96～2.18）的患病风险显著高于对照组。
      结论  甘油三酯–腰围表型可用于甄别正常BMI人群中的糖尿病高风险人群，可通过针对性干预措施进一步降低心血管代谢性疾病的发生风险。

     

    Abstract:
      Objective  To investigate the association between triglyceridemic waist and risk for prediabetes and diabetes in people in different body mass index (BMI) groups and provide evidence to improve the obesity management.
      Methods  Based on the data from early screening and intervention for population at high risk for cardiovascular diseas in Changning and Baoshan districts of Shanghai from 2016 to 2020, questionnaire survey, physical examinations and laboratory tests were conducted to collect the information about the sociodemographic characteristics, including lifestyle and disease history, anthropometric measurement, including body height and weight, and blood glucose or blood lipid indicators of this population. Multivariate logistic regression analysis was used to analyze the association between triglyceridemic waist phenotype and risk for prediabetes and diabetes in people in different BMI groups .
      Results  A total of 24 318 middle-aged and old participants were finally included in the study, in whom 11 536 were with normal triglycerides and waist circumference, 5 650 were with only abdominal obesity, 3 745 were with only high triglyceride, and 3387 were with high triglyceride and abdominal obesity (HTWC). HTWC was significantly associated with the higher risk for prediabetes and diabetes regardless of BMI level. Compare with the controls with normal triglycerides and waist circumference in each BMI groups, the odds ratios for prediabetes and diabetes in people were 1.46 (95%CI: 1.15–1.86) and 3.23 (95%CI: 2.44–4.25) in people with HTWC in normal BMI group, 1.55 (95%CI: 1.34–1.80) and 3.24 (95%CI: 2.67–3.96) in overweight people with HTWC, 1.43 (95%CI: 0.96–2.18) and 2.23 (95%CI: 1.32–3.95) in obese people with HTWC.
      Conclusion  The HTWC phenotype can be used to help identify high-risk groups of diabetes, even in people with normal BMI. Targeted interventions should be conducted to further reduce the risk for cardiometabolic diseases.

     

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