Objective  To analyze the burden of premature mortality and change trends of four chronic diseases (cardiovascular and cerebrovascular diseases, cancer, diabetes, and chronic respiratory diseases) in Xinjian district of Nanchang, Jiangxi province, from 2012 to 2021, and assess the achievement of the goal of reducing premature death probability of major chronic diseases in “Healthy China 2030”.

  Methods  The death data in Xinjian from 2012−2021were collected. Software R 4.2.0 and Joinpoint Regression Program 4.9.1.0 were used to calculate the crude death rate, years of life lost rate (YLL rate), probability of premature mortality, and average annual percentage change (AAPC) and χ² test was used for rate comparison. The temporal trend of each index was described using AAPC.

  Results  The overall crude mortality rate and YLL rate of the four chronic diseases in Xinjian from 2012 to 2021 were 544.87/100 000 and 109.91‰, respectively. There were decreasing trends in the overall standardized mortality rate, standardized YLL rate, and probability of premature mortality (P<0.05). The crude mortality rate, YLL rate and probability of premature mortality were higher in men than in women. The standardized mortality rate, standardized YLL rate and premature mortality probability of cardiovascular and cerebrovascular diseases all showed downward trends (P<0.05). The YLL rate and probability of premature mortality of cancer were 49.77‰ and 8.90%, respectively, the highest among the four chronic diseases. The probabilities of premature mortality of diabetes and chronic respiratory diseases had the most significant reductions.

  Conclusion  The burden of premature mortality of four chronic diseases in Xinjian was in decline, indicating that the goal of “Health China 2030” can be achieved. It is necessary to strengthen the prevention and control of cardiovascular and cerebrovascular diseases, cancers, especially in men.