张越, 毕若萌, 马建新, 李倩, 张政, 焦洋, 齐啸, 陈田木. 基于动力学模型对北京市一起水源性诺如病毒暴发疫情防控措施的效果分析[J]. 疾病监测, 2023, 38(8): 1007-1013. DOI: 10.3784/jbjc.202305150220
引用本文: 张越, 毕若萌, 马建新, 李倩, 张政, 焦洋, 齐啸, 陈田木. 基于动力学模型对北京市一起水源性诺如病毒暴发疫情防控措施的效果分析[J]. 疾病监测, 2023, 38(8): 1007-1013. DOI: 10.3784/jbjc.202305150220
Zhang Yue, Bi Ruomeng, Ma Jianxin, Li Qian, Zhang Zheng, Jiao Yang, Qi Xiao, Chen Tianmu. Evaluation of prevention and control measures for a waterborne norovirus outbreak in Beijing based on dynamic model[J]. Disease Surveillance, 2023, 38(8): 1007-1013. DOI: 10.3784/jbjc.202305150220
Citation: Zhang Yue, Bi Ruomeng, Ma Jianxin, Li Qian, Zhang Zheng, Jiao Yang, Qi Xiao, Chen Tianmu. Evaluation of prevention and control measures for a waterborne norovirus outbreak in Beijing based on dynamic model[J]. Disease Surveillance, 2023, 38(8): 1007-1013. DOI: 10.3784/jbjc.202305150220

基于动力学模型对北京市一起水源性诺如病毒暴发疫情防控措施的效果分析

Evaluation of prevention and control measures for a waterborne norovirus outbreak in Beijing based on dynamic model

  • 摘要:
      目的   针对北京市一起社区内介水传播的诺如病毒感染导致的急性胃肠炎暴发疫情进行传播动力学特征分析,对不同防控措施分别进行效果评价,探讨最佳防控措施。
      方法  对2019年北京市某小区一起诺如病毒感染所致的急性胃肠炎暴发疫情资料,建立易感者–潜伏期–显性/隐性感染者–移出者–传播介质(SEIARW)模型,对阻断水传播的措施、健康宣教、要求病例居家休息并禁止在社区内举办聚集性活动等隔离相关措施进行效果分析。
      结果  无干预状态下,此次疫情诺如病毒有效再生数为9.32,罹患率可达70.00%,疫情持续时间为45.26 d。 当阻断水传播的时间越早,罹患率越低,疫情持续时间越长。 健康宣教措施也可使疫情罹患率下降和流行曲线更低矮。 隔离相关措施可以缩短疫情持续时间,且隔离率越高,罹患率越低,当日采取措施比次日采取措施防控效果更好。 拟合得到疫情接报当日就采取阻断水传播的措施,同时进行健康宣教和在疫情接报当日采取隔离,隔离率为75.00%时,可达到最佳防控效果。
      结论  越早阻断水传播的措施、持续健康宣教和早隔离能在不同程度上有效控制暴发疫情。

     

    Abstract:
      Objective  To characterize the transmission dynamics of an outbreak of acute gastroenteritis caused by a community-transmitted waterborne norovirus infection in a district in Beijing, and to evaluate the effectiveness of different prevention and control measures to explore the best prevention and control measures.
      Methods  Statistical description of cases in a norovirus outbreak in Beijing 2019, are carried out while the Susceptible-Exposed-Infectious/asymptomatic-Removed-Water/food (SEIARW) dynamic model is performed at the same time. the impact of prevention and control measures including blocking waterborne transmission, health education, and requiring patients to stay at home and prohibiting gatherings and other isolation related measures.
      Results  Without intervention, the effective reproduction number of norovirus in this outbreak was 9.32, the incidence rate could be 70.00%, and the duration of the outbreak was 45.26 days. The earlier water transmission is interrupted, the lower the incidence rate and the longer the duration of the epidemic. Health promotion measures can also lead to lower incidence rates and lower epidemic curves. Isolation-related measures could shorten the duration of the epidemic, and the higher the isolation rate, the lower the incidence rate, and the better the prevention and control effect of same-day measures than next-day measures.The best prevention and control effect can be achieved when measures to interrupt water transmission are taken on the day the outbreak is reported, along with health promotion and isolation on the day the outbreak is reported, and the isolation rate is 75.00%.
      Conclusion  The earlier the measures to interrupt water transmission, continuous health education and early isolation can be effective in controlling outbreaks to varying degrees.

     

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