Abstract: In May 2023, a total of 69 infectious diseases were reported globally, affecting 235 countries and regions. Except for influenza, the top five infectious diseases affecting greatest number of countries and regions were coronavirus disease 2019(COVID-19) (235), monkeypox (111), dengue fever (28), measles (25) and cholera (24). The top five infectious diseases with highest case fatality rates were Marburg virus disease (83.7%), Lassa fever (17.2%), Anthrax (14.8%), Crimean-congo hemorrhagic fever (7.7%) and Meningitis (6.2%). The top five infectious diseases with greatest number of deaths were COVID-19, measles, dengue fever, cholera and meningitis. The prevalent infectious diseases in Asia were COVID-19, cholera, monkeypox, Crimean-congo hemorrhagic fever and dengue fever, the prevalent infectious diseases in Africa were COVID-19, cholera, yellow fever, Marburg virus disease, Lassa fever and meningitis, the prevalent infectious diseases in America were COVID-19, monkeypox, dengue fever and Chikungunya fever, the prevalent infectious disease in Europe were COVID-19 and invasive group A streptococcus infection.