Abstract: In August 2023, a total of 72 infectious diseases were reported globally, affecting 236 countries and regions. Except for influenza, the top five infectious diseases affecting greatest number of countries and regions were COVID-19 (236), monkeypox (114), dengue fever (31), measles (31) and cholera (16). The top five infectious diseases with highest case fatality rates were Middle East respiratory syndrome (36.0%), Lassa fever (16.9%), Crimean-congo hemorrhagic fever (11.8%), meningitis (6.7%) and West Nile disease (6.1%). The top five infectious diseases with greatest number of deaths were COVID-19, dengue fever, cholera, measles and diphtheria. The prevalent infectious diseases in Asia were COVID-19, cholera, monkeypox, Crimean-congo hemorrhagic fever and dengue fever, the prevalent infectious diseases in Africa were COVID-19, cholera, monkeypox, Lassa fever, meningitis and poliomyelitis, the prevalent infectious diseases in America were COVID-19, dengue fever, chikungunya fever and monkeypox, the prevalent infectious disease in Europe was West Nile disease.