刘学欣, 吴晓倩, 王晓曦, 陈文燕, 刘承浩, 刘增宾. 2023年河北省某医院23 817例受检者吸烟与幽门螺杆菌感染的相关性分析[J]. 疾病监测. DOI: 10.3784/jbjc.202404030216
引用本文: 刘学欣, 吴晓倩, 王晓曦, 陈文燕, 刘承浩, 刘增宾. 2023年河北省某医院23 817例受检者吸烟与幽门螺杆菌感染的相关性分析[J]. 疾病监测. DOI: 10.3784/jbjc.202404030216
Liu Xuexin, Wu Xiaoqian, Wang Xiaoxi, Chen Wenyan, Liu Chenghao, Liu Zengbin. Analysis on correlation between smoking and Helicobacter pylori infection in 23 817 subjects in a hospital in Hebei, 2023[J]. Disease Surveillance. DOI: 10.3784/jbjc.202404030216
Citation: Liu Xuexin, Wu Xiaoqian, Wang Xiaoxi, Chen Wenyan, Liu Chenghao, Liu Zengbin. Analysis on correlation between smoking and Helicobacter pylori infection in 23 817 subjects in a hospital in Hebei, 2023[J]. Disease Surveillance. DOI: 10.3784/jbjc.202404030216

2023年河北省某医院23 817例受检者吸烟与幽门螺杆菌感染的相关性分析

Analysis on correlation between smoking and Helicobacter pylori infection in 23 817 subjects in a hospital in Hebei, 2023

  • 摘要:
    目的 探讨吸烟与幽门螺杆菌感染的相关性,用以提供健康指引和管理依据。
    方法 研究人群为2023年在河北省人民医院健康管理中心查体、年龄≥18岁的 23817 例受检者,用13C 尿素呼吸试验检测幽门螺杆菌感染情况,收集年龄、性别、体重等人口学、吸烟和饮酒等行为习惯及血常规和肝功能等指标,通过t检验、χ2检验和多因素 logistic 回归分析吸烟与幽门螺杆菌感染之间的相关性。
    结果 感染幽门螺杆菌的比例为33.30%。男性幽门螺杆菌的感染率高于女性(58.79% vs. 41.21%,χ2=12.144,P<0.001),幽门螺杆菌感染受检者中,吸烟和饮酒比例、超重和肥胖比例、身高、体质量、腰围、收缩压、舒张压、肌酐、尿酸、空腹血糖、总胆固醇、低密度脂蛋白胆固醇、甘油三酯、γ-谷氨酰基转移酶、天冬氨酸转氨酶水平高于幽门螺杆菌非感染受检者,而高密度脂蛋白胆固醇水平和高血压的比率低于幽门螺杆菌非感染受检者。 年龄、尿素氮、丙氨酸氨基转移酶和糖化血红蛋白水平两组之间差异没有统计学意义(均P>0.05)。 多因素 logistic 回归分析结果均显示,与不吸烟组相比,吸烟组感染幽门螺杆菌的风险增加0.13倍(比值比为1.13;95%的置信区间为:1.03~1.24,P=0.009)。
    结论  吸烟是幽门螺杆菌感染的危险因素,控制吸烟对幽门螺杆菌的防控具有一定的临床价值。

     

    Abstract:
    Objective To explore the correlation between smoking and Helicobacter pylori infection and provide evidence health promotion and management.
    Methods A total of 23817 subjects aged ≥18 years who received health examination in Hebei Provincial People’s Hospital in 2023 were selected for the detection of H. pylori infection by 13C urea respiratory test, and the information about their demographic characteristics, such as age, gender and body weight, the lifestyle, such as smoking and drinking, and the indicators such as blood and liver functions were collected for the analysis on the correlation between smoking and H. pylori infection by t test, χ2 test and multivariate logistic regression analysis.
    Results The prevalence of H. pylori infection was 33.30%. The prevalence of H. pylori infection was higher in men (58.79%) than in women (41.21%) (χ2=12.144, P<0.001), and the rates of smoking and alcohol consumption, overweight and obesity, height, weight, waist circumference, systolic blood pressure, diastolic blood pressure and the levels of creatinine, uric acid, fasting plasma glucose, total cholesterol, low-density lipoprotein cholesterol, triglyceride, γ-glutamyl transferase, and aspartate amino transferase were higher in the subjects with H. pylori infection than in the subjects without H. pylori infection, while the subjects with H. pylori infection had lower high-density lipoprotein cholesterol levels and rates of hypertension compared with those without H. pylori infection. There were no significant differences in age, urea nitrogen, alanine transferase and glycosylated hemoglobin A1clevels between the two groups (all P>0.05). All results of multivariate logistic regression analysis showed that the smoking group had a 0.13 higher risk for H. pylori infection compared with the non-smoking group (odds ratio=1.13; 95% confidence interval: 1.03–1.24, P=0.009).
    Conclusion Smoking is a risk factor for H. pylori infection, and smoking control has clinical value in the prevention and control of H. pylori infection.

     

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