Study on Strategy with Low-and Non-Response to HBV Vaccine in Infants

In order to explore the best boaster strategy for children with low-and non-response to HBV vaccine, a randomized controlled trial for evaluation of simple HBV vaccine (30μg×3) and HBV vaccine (30μg×3) combined with Mycobacteria Phlei Polysaccharides (MPS, MPS-A 20μg/ml×15, MPS-B 2μg/ml×15) was conducted in 59 infants of HBsAg positive mothers. The infants with low-and non-response were tested for HBV-DNA using PCR, only 3.8% were infected with HBV, most of the infants were free of HBV infecion. Therefore,the booster vaccination with the HB vaccine and MPS was necessary,especially for children of HBsAg positive mothers.