The Relationship between the Reincreasing Rate of Rabies and the Quality of Vaccine in Some Provinces in China 1997

The morbidity of rabies was increased again in some provinces of China 1997. The re-increasing rate was 39.6%(222/159) but it was very apparent in Jiangxi (285.7%, 27/7), Jiangsu (109.1%,23/11) and Guangxi (108.3%, 50/24). The cause may be related to the quality of vaccine. For instance, the antibody titer of post-vaccination was decreased yearly. The positive converse rate was decreased from 91.3%(543/595) in 1994 to 68% (295/432) in 1998. Even using the vaccine made by the same factory, the positive converse rates after 2nd and 3rd vaccination in 1996 were decreased by 18% and 46% in comparison with 1994(p<0.05).Furthermore two cases without any effect were reported.National control center showed a similar tendency.The expected morbidity of rabies in 1998 in China was forecased.