The Relationship Between the Genotype of HCV and HCC

Objective To realize the distribution and relationship between Hepatocellular Carcinoma (HCC) and genotype of HCV. Method 43 of HCV-RNA positive sera were selected. They were 13 of confirmed Hepatocellular carcinoma HCC) cases, 15 of other cancer cases and 15 of professionals in public services. Genotyping of HCV RNA was conducted using type specific primers induced from core region of HCV on these samples. Result 12 samples were genotyping positive and only 1b (100%) was found in HCC cases. There had not only 1b(13/15 86.67%),2a(6.67%)and 1d/2a(6.67%)mixture were found in professionals of public services. No genotype of 1a,2b,and 3a were detected. The distribution rate of 1b,2a and 1b/2a mixture was 90.48%,7.14% and 2.38% respectirely,The predominant genotype was 1b.Conclusion The genotype of HCV-RNA 1b was related with HCC. It was also the predominant genotype of HCV in Shanxi.