Management of acute organophosphorus pesticide poisoning with penehyclidine hydrochloride

Objective The present study was conducted to explore the function and advantages of Changtuoning (Penehyclidine Hydrochloride Injection) in treating acute organophosphorus pesti-cide poisoning．Methods 56 cases with oral organophosphorus pesticide poisoning were randomly divided into the control group and the therapeutic group．Patients in the control group were treated with Atropine and Pralidoxime Chloride，and in the therapeutic group were treated with Penehycli-dine Hydrochloride and Pralidoxime Chloride．Results Compared to the control group，atropiniza-tion time，acetylcholine esterase recovery time，total cure rate and average days in hospital were better in the Penehyclidine Hydrochloride group than the Atropine group．There were significant differences between the two groups and the incidenee of side reactions in Penehyclidine Hy-drochloride group was lower with fewer symptoms．Even though side effects occurred，they were easier to recover or be corrected．Conclusion The efficacy of Penehyclidine Hydrochloride in treating organophosphorus pesticide poisoning was significantly better than that of Atropine．So Penehyclidine Hydrochloride is worth generalizing and applying clinically．